SCIEX launches novus V55 triple quadrupole mass spectrometer at ASMS 2026
Next-generation system combines high sensitivity, compact design, and AI-enabled software to improve laboratory efficiency and throughput
2 Jun 2026Product news
SCIEX has launched a next-generation triple quadrupole mass spectrometer at ASMS 2026 in San Diego, USA. The novus V55 system is designed to help high-pressure, results-driven analytical laboratories deliver more data in less time, space, and energy. It provides exceptional sensitivity and accelerated quantitative output in a smaller, more energy-efficient footprint than the SCIEX 5500+ system, supporting applications such as pesticide and food analysis, pharmaceutical impurity testing, bioanalysis, PFAS testing, and additional quantitative workflows.
Next-generation triple quadrupole performance
The novus V55 system is engineered for business impact and real-world analytical workflows. It features aeMRM (accelerated MRM), which can acquire up to 1,000 MRMs per second. This capability increases sample throughput, expands testing panels, and maintains quantitative accuracy, supporting laboratories that need to process large sample volumes without compromising data quality.
SCIEX OS 5.0 software with AI enablement
The novus V55 system is launched together with SCIEX OS 5.0 software, introducing new features designed to streamline mass spectrometry workflows and support data integrity.
Key features of SCIEX OS 5.0 software include:
- Central Metrics Tracker for tracking performance and assay-level metrics
- Central Monitoring to display instrument status across an entire instrument fleet
- Reporter Template Creator to easily build customized reports
- AI enabled 'helpme' function to answer feature and functionality questions quickly using a natural language interface
- AI enabled Calculated Columns to create custom calculations for columns using natural language
These software and AI tools are designed to simplify method development, reporting, and system oversight for LC-MS/MS laboratories.
Robust OptiFlow source technology
The novus V55 system incorporates the OptiFlow source, built on the same technology trusted by thousands of customers worldwide. This source upholds the robustness and sensitivity that are synonymous with SCIEX systems, supporting reliable performance in demanding, high-throughput environments.
Smaller footprint and reduced energy consumption
The novus V55 system delivers performance enhancements while reducing resource requirements:
- 35% smaller footprint, making it the most compact triple quadrupole in its class without compromising sensitivity or quantitative performance
- 40% reduction in both energy consumption and laboratory cooling requirements, helping laboratories lower operational energy costs
These improvements support laboratories seeking to optimize space utilization and meet sustainability and cost-reduction goals.
Compliance, connectivity and integration
The novus V55 system is designed to integrate into existing laboratory infrastructures. It offers:
- Compatibility with any LC system
- LIMS support
- 21 CFR Part 11 support to help maintain compliance and operational confidence
This connectivity enables laboratories to incorporate the novus V55 system into regulated and non-regulated workflows while maintaining data integrity and traceability.
“Analytical labs are being asked to deliver more insight with less time, space, and energy. With the novus V55 system, we have applied decades of innovation to ensure robustness and sensitivity, while enhancing performance and execution. This new generational instrument will help enable our customers to drive their business forward,” says Chris Lock, Vice President Global Research and Development at SCIEX.
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Frequently asked questions
What is the SCIEX novus V55 triple quadrupole mass spectrometer and which analytical applications does it support?
The SCIEX novus V55 is a next-generation triple quadrupole mass spectrometer from SCIEX. It is designed for high-pressure, results-driven analytical laboratories that need to deliver more data in less time, space, and energy. It supports a wide range of quantitative LC-MS/MS applications, including pesticide residue analysis, food safety testing, pharmaceutical impurity profiling, bioanalysis, PFAS testing, and additional quantitative assays.
How does the novus V55 system improve throughput, sensitivity, and energy efficiency compared with previous SCIEX triple quadrupole instruments?
The novus V55 system delivers exceptional sensitivity and accelerated quantitative output in a more compact and energy-efficient design than the SCIEX 5500+ system. It features aeMRM (accelerated MRM) technology capable of acquiring up to 1,000 MRMs per second, which increases sample throughput, enables larger testing panels, and maintains quantitative accuracy.
The instrument has a 35% smaller footprint, making it the most compact triple quadrupole in its class, and achieves a 40% reduction in both energy consumption and laboratory cooling requirements, helping laboratories optimize space and reduce operational energy costs while maintaining the sensitivity and quantitative performance associated with SCIEX instruments.
What software, AI capabilities, and connectivity features are included with the SCIEX novus V55 system for regulated LC-MS/MS laboratories?
The novus V55 system is launched together with SCIEX OS 5.0 software, which introduces tools to streamline mass spectrometry workflows and support data integrity. Key features include a Central Metrics Tracker for performance and assay-level metrics, Central Monitoring for viewing instrument status across an entire fleet, a Reporter Template Creator for customized reports, an AI-enabled 'helpme' function that answers feature and functionality questions via natural language, and AI-enabled Calculated Columns to build custom column calculations using natural language.
The system incorporates robust OptiFlow source technology for reliable, high-throughput performance and offers compatibility with any LC system, LIMS support, and 21 CFR Part 11 support to help maintain compliance and operational confidence in both regulated and non-regulated workflows.