SCIEX introduces new data-independent acquisition, ZT Scan DIA, at ASMS 2024

Delivering the depth of coverage characteristic of DIA approaches, with the precision, sensitivity and selectivity of targeted quantitative workflows

3 Jun 2024

SCIEX, a global leader in life science analytical technologies, has introduced ZT Scan DIA for LC-MS/MS, the next generation in data-independent acquisition (DIA) that leverages the combination of the quadrupole dimension with the rich MS2 data attainable from the Zeno trap at ASMS 2024.

DIA allows for the measurement of all compounds within a sample in a targeted manner. It has been a central catalyst for shifting mass spectrometry from a discovery science to one that facilitates longitudinal studies, as required in clinical research and precision medicine research. However, the challenge remained to improve throughput and depth of coverage in proteomic measurements while maintaining consistency and quantitative precision.

ZT Scan DIA follows SWATH DIA and most recently, Zeno SWATH DIA, delivering the depth of coverage characteristic of DIA approaches but with the precision, sensitivity and selectivity of targeted quantitative workflows.

  • ZT Scan DIA can be leveraged to quantify more proteins at higher precision than previous DIA workflows, bridging the gap between ID and translation and delivering quantitative biological insight, that can inform disease understanding and efficacy of biomarkers.
  • Crucial pathway decisions with precise quantitative outcomes can be made up to 10X the speed of previous DIA workflows from SCIEX. Scientists can precisely quantify proteins, providing translational certainty that can be accurately validated at scale.
  • Analyse low protein loads at greater speeds than conventional DIA within biomarker discovery and development, to reduce uncertainty in quantitative protein measurements. Scientists can target, validate and translate, adding additional certainty in quantitative measurement.

To further optimize the potential of proteomic depth enabled by ZT Scan DIA, SCIEX has announced a collaboration with Bioinformatics Solutions Inc. (BSI), a provider of next-generation, deep learning proteomics solutions, AI-driven biotechnology solutions.

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