Sapient launches DynamiQ Normal Human Tissue Proteomics Atlas

Sapient has launched the DynamiQ™ Normal Human Tissue Proteomics Atlas, a comprehensive reference map of protein expression, signaling activity, cell surface accessibility, immune biology, and resistance pathways across more than 12,000 proteins in diverse normal human tissues.

The atlas enables drug development teams to systematically evaluate where therapeutic targets are expressed in normal human organs, quantify expression relative to tumor or diseased tissue, and identify organs at risk for on-target, off-tissue toxicity, supporting safer and more effective target selection decisions.

Comprehensive proteomics atlas of normal human tissue biology

The DynamiQ Normal Human Tissue Proteomics Atlas provides drug developers with a proteome-wide view of normal human biology across more than 15 tissue types, including heart, liver, lung, kidney, and other primary organs commonly associated with dose-limiting toxicities. By enabling direct queries of target protein expression across these tissues, the atlas helps teams quantify tumor-to-normal expression ratios and rank-order candidate targets based on their potential therapeutic index.

Beyond expression levels, the atlas incorporates baseline signaling, immune, and resistance pathway data to reveal organ-level vulnerabilities and potential immune-related adverse events. This integrated view of protein abundance, activation state, and biological context is designed to support proactive evaluation of safety liabilities before programs advance into clinical development.

By integrating multiple proteomics modalities, the atlas offers a unified framework for understanding how therapeutic targets behave in normal human tissues, helping teams anticipate safety risks and refine their development strategies.

Multi-dimensional proteomics profiling across 12,000+ proteins

Sapient uses its mass spectrometry-based proteomics platform to profile each normal human tissue across multiple biological dimensions:

• Global protein expression across more than 12,000 protein groups via DiscoverySeek™
• Cell surface protein expression via SurfaceSeek™
• Phosphorylation-driven signaling pathway activity via SignalingSeek™
• Immune cell composition and activation states via ImmuneSeek™
• Baseline survival and stress response pathways via ResistanceSeek™

Through this comprehensive proteome-wide characterization, the DynamiQ Normal Human Tissue Proteomics Atlas reduces reliance on indirect proxy measurements of protein levels, such as RNA expression databases or single-cell RNA sequencing data. Instead, it delivers direct and diverse protein quantification to inform target selection, safety assessment, and translational strategy.

Enabling earlier, data-driven safety and target selection decisions

By providing a detailed map of protein expression and activity in normal tissues, the DynamiQ Normal Human Tissue Proteomics Atlas allows researchers to identify organs at risk for toxicity, evaluate potential immune-related adverse events, and prioritize targets with more favorable safety profiles. This supports more informed decision-making from early discovery through to clinical development.

Flexible access models for biopharma and translational research teams

The DynamiQ Normal Human Tissue Proteomics Atlas is available through flexible data licensing and proteomics services models. Options include data access for specific targets of interest, integration of atlas data with internal workflows, and custom proteomics studies using client-provided samples.

These access models are designed to support a wide range of applications, from early-stage target discovery and validation to IND-enabling safety studies and clinical development programs.

“This atlas does not simply catalog which proteins are present in normal tissues – it reveals how proteins are regulated, activated, and organized across normal human biology,” said Dr. Mo Jain, Founder and Chief Scientific Officer at Sapient.

“Unlike transcriptomic databases or low-plex immunohistochemistry, we are delivering direct and diverse protein measurements across the proteome – encompassing abundance, surface accessibility, signaling state, immune context, and resistance pathway biology – as a comprehensive reference framework that can be applied from early discovery to target selection, IND-enabling programs, and clinical development.”

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