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RapidFire® Label-free High-Throughput Screening Solutions at LabAutomation 2010

20 Jan 2010
Sarah Sarah
Marketing / Sales

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Visit booth 368 to learn about RapidFire® HTMS instruments and assay development services from BIOCIUS Life Sciences.

BIOCIUS’s Dr. Maxine Jonas will also give a talk entitled, “The RF-300, an integrated automated SPE-MS System for high-throughput ADME sample analysis” on Wednesday, January 27 at 9:00 am, (Look for Track: High throughput Technologies, Session: Parallel Process Advances). To arrange a private in-person meeting while at the conference, please send a message to info@biocius.com.

RapidFire mass spectrometry greatly decreases the bottlenecks that occur during drug discovery. By enabling automated sample preparation at a rate of up to six seconds per sample and integrating seamlessly to the mass spectrometer, RapidFire enhances high-throughput screening of candidate drug compounds and in vitro ADME assays.

RapidFire allows for the analysis of a wide range of otherwise intractable targets such as triglycerides, lipids, fatty acids, prostaglandins, steroids, coenzyme A derivatives, neurotransmitters, epigenetic targets, anti-fungals and anti-infectives, which are difficult to study using traditional methods such as fluorescence or radiolabels. The RapidFire system can be used for a variety of in vitro ADME applications, including: CYP inhibition, metabolic stability, P-glycoprotein inhibition, plasma protein binding, permeability assays - Caco, PAMPA and CYP induction. RapidFire hardware is available as a solution in our collaborators' laboratories or as a contract research service in the BIOCIUS laboratory.

Spun out from BioTrove in December 2009, the RapidFire business unit formed BIOCIUS Life Sciences to provide the biopharmaceutical industry with faster answers: products and services committed to speed and accuracy in drug discovery. Used by 13 of the top 15 pharmaceutical companies, BIOCIUS’s products and contract research services enable our partners to exceed their business goals. For more information, select from the Related Resources below or visit the company website.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Solid-Phase ExtractionSolid-phase extraction (SPE) is used for clean-up, extraction and concentration of semi-volatile or non-volatile analytes from complex mixtures including blood, urine and food samples. Multiple formats are available for conducting SPE, including prepacked SPE cartridges, disks and microplates, as well as SPE sorbent powders for manual packing. SPE systems can be used to automate the process and extract multiple samples at once. Solid-phase microextraction (SPME) and supported liquid extraction (SLE) products are also available in the same formats. Find the best SPE, SLE and SPME equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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