SelectScience
Join Free
ResourceLife Sciences

Precision CNS-specific biomarker measurement for Alzheimer’s disease

Spear Bio
12 Feb 2026

Plasma phosphorylated tau at threonine 217 (pTau 217) is currently the most effective blood biomarker for Alzheimer’s disease, demonstrating strong concordance with amyloid-β (Aβ) and tau PET imaging and the largest fold difference between amyloidnegative and amyloid-positive individuals.

This application note evaluates the performance of the SPEAR UltraDetect™ BD-pTau 217 Assay, designed to target CNS-specific pTau 217 species, in a memory clinic cohort and in a cohort of young healthy individuals.

Related products

Request Quote for All Products

SPEAR UltraDetect™ BD-pTau 217 Assay Kit

Spear Bio

The SPEAR UltraDetect™ BD-pTau 217 Assay enables highly sensitive and precise quantification of brain-derived pTau 217 in plasma. The only BD-pTau 217 assay delivering 100% quantifiability across healthy and diseased samples using just 1 µL of diluted plasma in a homogenous, wash-free format — enabling robust early detection, stratification, and longitudinal analysis of this ultra-low abundance biomarker. Verified for plasma samples. For research use only.

(0)

Links

Spear BioCompany website

Tags

BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Alzheimers ResearchAlzheimer�s disease is a neurodegenerative condition characterized by progressive memory loss and cognitive decline. Research focuses on understanding the molecular and cellular mechanisms of the disease, as well as developing effective treatments and diagnostic tools. Browse our peer-reviewed product directory to find the best Alzheimer�s research products, compare options, check reviews, and get pricing directly from manufacturers.ImmunoassayImmunoassays are laboratory tests that utilize antibody-antigen interactions to detect specific substances. They are widely used in diagnostics for detecting diseases, drug testing, and environmental monitoring. These assays offer rapid, sensitive, and precise detection of biomarkers, making them invaluable in clinical and research labs. Browse our peer-reviewed product directory to compare immunoassay systems, read user reviews, and get pricing directly from manufacturers.NeurodegenerationNeurodegeneration refers to the progressive deterioration of the structure and function of the nervous system, often seen in diseases like Alzheimer's and Parkinson's. Research focuses on early detection and potential therapies. Explore neurodegeneration research tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Alzheimers Disease

Related resources