Pfizer Inaugurates Center of Excellence in Precision Medicine in Chile with Strong Focus on Genomics

Work conducted at Center to revolutionize diagnosis and treatment of cancer globally, selects Thermo Fisher Scientific as technology partner

8 Jul 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Industry news

In an event that was attended by government officials, prominent scientists, academics, and company leaders, Pfizer today inaugurated its Center of Excellence in Precision Medicine (CEPM, for its acronym in Spanish). The center, one-of-its-kind in Latin America, will initially focus on validating new technologies of molecular cancer diagnosis that are more exact and less invasive.

"CEMP is the result of a joint effort between the Chilean government and Pfizer, at a global and local level, which showcases our mutual interest in raising the level of applied science done in our country, and in promoting Chile as an innovation hub in terms of R+D,” said Pfizer Chile General Manager Carlos Murillo.

The Center has the support of the Chilean Economic Development Agency’s (Corfo) program to attract international Centers of Excellence, which seeks to position Chile as a hub for research, development and innovation in the region. In this context, Corfo will provide co-financing of USD$7 million, over a period of four years, which added to the USD$14 million from Pfizer, make up a total investment of USD$ 21 million required for the Center’s development and operations.

"In Chile, we have very good scientific productivity; however, we have not been able to transform that knowledge into actual products and services that improve both the productivity of industries and the quality of life of people. By developing this type of strategic partnerships, we will be able to further our country’s capabilities for research, development, and innovation of excellence, as well as position Chile in the map of innovation centers at a regional and global level,” said Marcela Angulo, Corfo’s Manager for Technological Capabilities.

Breakthrough research in oncology

In its first stage, CEPM’s research will focus on the field of lung oncology, seeking to validate new technology platforms for molecular diagnostics based on next-generation genomic sequencing.

"Non-small cell lung cancer, which we will be analyzing at CEPM during its initial phase, has a high incidence in Chile and the region. In Chile, it is estimated that there are between 1,800 and 2,100 cases a year," said Sylvia Varela, President of Pfizer Oncology for Latin America. “At Pfizer, our priority is to develop innovative therapies that improve and prolong the lives of patients. CEPM, which opens its doors today in Santiago, illustrates that commitment in a very definite way. Precision medicine offers one of the best opportunities we have to develop medicines that have a greater positive impact on patients. The work that will be done at CEPM will be on par with the best and most renowned research centers in the world,” she added.

"Analyzing the DNA of a tumor is critical to understanding the disease and consequently adopting more effective and personalized treatment practices that provide the best results according to the patient's genetic information. For this task, the Ion PGM (Personal Genome Machine) was selected because it is a revolutionary DNA sequencer that uses next-generation sequencing technology to perform full analysis,” explains Roberto Mendes, President of Thermo Fisher Scientific Latin America, the Center’s technology partner, which invested US $3 million in its first project with CEMP. The studies conducted at CEPM will comply with the strictest protocols and international standards required for the approval of new technologies by international regulatory agencies. CEMP Executive Director Gloria Maldonado concluded the ceremony stating that "CEMP’s contribution to the national ecosystem is essential because it will allow us to share faster the results of our research with the hospitals and patients who need it most.”

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ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.DNADeoxyribonucleic Acid (DNA) is the main component of chromosomes and the carrier of genetic information of living organisms. Find out here about PCR, NGS, ChIP-Seq, gel imaging, and many other techniques which can be used for the analysis of DNA.Lung CancerLung cancer is a leading cause of cancer-related deaths worldwide, often diagnosed at an advanced stage. Research focuses on early detection, targeted therapies, and personalized treatment strategies. Explore lung cancer research and diagnostic products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Molecular DiagnosticsMolecular diagnostics use an individual’s genetic code and gene expression to diagnose and monitor diseases. The technique is used increasingly in the field of infectious diseases and oncology, as well as areas such as coagulation, HLA typing and pharmacogenomics. Molecular diagnostics plays a pivotal role in personalized medicine.TherapeuticsTherapeutics are treatments designed to alleviate or cure diseases. These include pharmaceuticals, biologics, and gene therapies, which work by targeting specific disease mechanisms. Advances in personalized medicine and biologics offer new hope for patients with conditions that were previously difficult to treat. Browse our peer-reviewed product directory to find therapeutic solutions for various diseases; compare products, check user reviews, and get pricing directly from manufacturers.TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.Precision MedicinePrecision medicine refers to the idea of customized healthcare, where medical decisions and treatments are tailored to the individual patient. Molecular diagnostics, companion diagnostics and Next Generation Sequencing (NGS) play a pivotal role in this approach. Precision MedicinePrecision medicine refers to the idea of customized healthcare, where medical decisions and treatments are tailored to the individual patient. Molecular diagnostics, companion diagnostics and Next Generation Sequencing (NGS) play a pivotal role in this approach.
Pfizer Inaugurates Center of Excellence in Precision Medicine in Chile with Strong Focus on Genomics