PerkinElmer Launches Signals™ for Translational New Cloud-Based Informatics Platform Supports Complete Precision Medicine Workflow

28 Oct 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

PerkinElmer, Inc., a global leader focused on improving the health and safety of people and the environment, has announced the launch of PerkinElmer Signals™ for Translational, a cloud-based data management, aggregation and analysis platform for pharmaceutical researchers. This new offering integrates experimental and clinical research data from many sources and relates the data to scientifically meaningful concepts. It also enables support for the complete precision medicine workflow, from data acquisition to biomarker discovery and validation.

Co-developed with top pharmaceutical companies, PerkinElmer Signals™ for Translational is designed to help researchers easily integrate experimental and clinical data from existing proprietary databases, private and public databases such as GEO and tranSMART, and connect with other enterprise systems. With more than 90 percent of the top 25 pharmaceutical companies engaged in translational research, PerkinElmer Signals™ for Translational supports greater collaboration and enables traditional scientists to increase the speed and efficiency of developing drugs tailored to patients’ unique health needs.

“PerkinElmer Signals for Translational helps provide the foundation for new research and development opportunities,” says Christopher Conway, Senior Vice President, Discovery and Development Services at Albany Molecular Research, Inc. (AMRI). “We are integrating the new solution into the cell::explorer instrumentation, a robotic automation platform for our high content screening applications located at AMRI’s integrated drug discovery center in Buffalo, New York. This will significantly enhance our ability to quickly acquire, manage, integrate, and analyze large, complex data sets from the various translational platforms, ultimately accelerating knowledge and information pass-through for better and faster drug discovery.”

PerkinElmer Signals™ for Translational provides access to data via a simplified user interface and a data model specifically designed to support translational research through the identification and management of biomarkers. It streamlines the sharing of data between pharmaceutical stakeholders and their partners in biotech, academic and contract research organizations.

“In the past, translational researchers could not intuitively engage with available data, which made searching for and accessing integrated data to identify and characterize biomarkers extremely challenging,” said Karen Madden, President, Informatics at PerkinElmer. “This new translational platform’s ability to enhance collaboration and eliminate silos between research and clinical data represents a significant step toward advancing precision medicine, ensuring optimal pairing between patients and drugs, and achieving better outcomes in human health.”

PerkinElmer Signals™ for Translational is delivered in a Software as a Service (SaaS) model to help lower cost and provide flexibility and scalability for pharmaceutical IT operations. It is fully integrated with TIBCO Spotfire® self-service analytics software to enable translational scientists to more easily manage and explore the data from acquisition to analysis and visualization. Researchers can also:

  • Store structured and unstructured data, including the output from bioinformatics or data scientists’ processing pipelines
  • Easily query, extract, identify, and store information for entities, like subjects or samples, that are relevant to translational medicine analysis; and
  • Normalize the representation of stored data.

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Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Discovery SoftwareComputational techniques used in both the chemistry and biology aspects of drug discovery, for data acquisition, processing and storage. Software is used for analysis of pathways, target identification, genomics, proteomics, modelling, lead identification, compound analysis and drug modelling among many others. Development SoftwareComputational techniques used in both the chemistry and biology aspects of drug development, for data acquisition, data analysis, processing and storage. Software is used for analysis of ADME results, toxicology, clinical trials and regulatory processes. RegulatoryPharmaceutical regulations impact on all areas of drug development, manufacture and control and supply. Services are provided from the early stages of drug development and clinical trials through to dossier submission, approval and marketing. Regulatory also includes submission of analytical studies from the pharmaceutical product and safety. Precision MedicinePrecision medicine refers to the idea of customized healthcare, where medical decisions and treatments are tailored to the individual patient. Molecular diagnostics, companion diagnostics and Next Generation Sequencing (NGS) play a pivotal role in this approach. PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Method ValidationMethod validation is the process used to prove that the analytical procedure used for a particular test is capable of providing suitable data.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.
PerkinElmer Launches Signals™ for Translational New Cloud-Based Informatics Platform Supports Complete Precision Medicine Workflow