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PerkinElmer has launched the first cell painting kit

PerkinElmer

New PhenoVue™ cell painting reagent kit makes the process of “painting” cells easier for research scientists by providing carefully selected and pre-optimized reagents

19 Feb 2021
Ellen Simms
Product and Reviews Editor

Product news

PerkinElmer, Inc., one of the global leaders committed to innovating for a healthier world, has launched the first cell painting kit as part of its new portfolio of PhenoVue™ cellular imaging reagents.

This new range of reagents leverages PerkinElmer’s expertise in cellular imaging and high-content screening and works alongside the Company’s microplates, automation, software and industry-leading high-content screening instruments. With this entire screening workflow, researchers can better understand disease and develop more pinpointed therapies and drugs to treat them.

Cell painting is a powerful application of high-content screening technology which combines cell and computational biology to study the effects of perturbagens such as chemical compounds, drugs or genes on the behavior of cells. Cells are “painted” by labelling cellular compartments with different fluorescent bioprobes to enable those areas to be quantitatively profiled. However, preparing reagents from scratch can be incredibly time consuming.

Helping to address this challenge, the PhenoVue™ cell painting kit provides convenience and simplicity through a ready-to-use format and is part of a new range of reagents that also includes fluorescent organelle staining probes and dye-labelled secondary antibodies. These reagents are validated for high-content screening applications to reduce customers’ assay development time.

For example, customers can use these reagents with PerkinElmer’s CellCarrier™ Ultra microplates, the PerkinElmer Opera Phenix® Plus high-content screening system, Operetta CLS™ high-content analysis system and Harmony® high-content analysis software.

“Researchers are using high-content screening and cell painting to make extraordinary discoveries that will help drive more innovative drugs and therapies,” said Alan Fletcher, Vice President and GM of Life Sciences, PerkinElmer. “With the addition of our new PhenoVue™ cellular imaging reagents, we now offer a complete suite of high-content screening products and expert services. This will help researchers build more streamlined workflows and enjoy the convenience of working with a single, expert technology provider helping to accelerate discovery.”

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Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Cell ImagingCell imaging can be achieved using a number of techniques including confocal microscopy, transmission electron microscopy, atomic force microscopy, and light sheet microscopy.High Content ImagingHigh content imaging is a method combining two or more fluorescent microscopy experiments to identify substances that alter a cell’s phenotype in a desired manner. The process is adapted to multi-well plates and both the image acquisition and analysis are automated.

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PerkinElmer has launched the first cell painting kit