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New UV-Vis Spectrophotometer Simplifies Sample Quality Decisions

Thermo Fisher Scientific

Thermo Scientific NanoDrop One spectrophotometers designed to identify contaminants, providing accurate concentrations

5 Oct 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

Life scientists who work with DNA, RNA and proteins can make educated decisions about sample suitability in experiments using a standalone, microvolume spectrophotometer for accurate quantitation and purity measurements to ensure downstream application success.

The Thermo Scientific NanoDrop One and NanoDrop OneC UV-Vis microvolume spectrophotometers are designed to help life science researchers gain a more complete understanding of sample quality and avoid costly delays due to troubleshooting and repeating experiments. These new spectrophotometers introduce the Thermo Scientific Acclaro Sample Intelligence technology, which enables researchers to:

  • Identify sample contaminants and obtain corrected concentration results;
  • Receive instant feedback about sample quality with on-demand technical support and guided troubleshooting; and
  • Confidently measure samples with embedded sensor and digital image analysis.

“Building on the success of previous NanoDrop instruments, used by thousands of scientists worldwide, we have designed the NanoDrop One instrument to provide simplicity and speed as well as information on sample quality. This allows scientists to accurately quantify and qualify nucleic acid and protein samples, so they can make informed decisions on sample use in downstream applications,” said Dr. Voula Kodoyianni, product manager, molecular spectroscopy, Thermo Fisher Scientific.

The NanoDrop One instrument with its high-resolution, touchscreen interface makes it simple to use as a compact, ergonomic instrument, while the powerful auto-range pathlength technology facilitates accurate measurements for concentrated samples with no need for dilutions.

The patented NanoDrop sample-retention system measures 1-2 µL of sample in seconds without the need for cuvettes, making it a cost- and time-effective solution for busy labs. Workflows can be streamlined on the NanoDrop One instrument with the Auto-Measure functionality, while modern connectivity allows results to be shared and archived via Wi-Fi, Ethernet or USB. The NanoDrop OneC instrument contains both pedestal and cuvette measuring positions, increasing dynamic range and assay flexibility.

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Atomic Absorption / Emission SpectroscopyAtomic absorption spectroscopy (AAS) and atomic emission spectroscopy (AES) — also called optical emission spectroscopy (OES) — are used to detect the elemental constituents in samples. Both techniques involve the atomization of a sample. Atomic absorption spectrometers may use a flame or furnace to create an atomic vapor of the sample before irradiation with spectral light. Optical emission spectrometers may use a flame, inductively coupled plasma (ICP), microwave plasma (MP) or spark arcs to atomize and excite the sample. At higher excitation energies, electrons can be emitted instead of photons, which can be useful for samples that can’t be atomized and for surface analysis. Explore electron spectroscopy equipment such as Auger spectrometers and photoelectron spectrometers for surface elemental analysis of samples. Find the best atomic absorption, photoelectron and optical emission spectrometers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.RNA InterferenceRNA interference (RNAi) uses siRNA or miRNA for transcriptional silencing, gene knockdown and regulation of gene expression. RNAi requires chemical synthesis, introduction of DNA vectors into cells, an assay of RNAi effects and RNAi quantification or analysis. Consider target sequence selection, reagent preparation, controls, high specificity and effectiveness and low non-specific gene knockdown.Protein QuantificationThe detection and quantification of proteins in a sample is vital across life sciences, pharmaceutical research and clinical diagnostics, and a variety of equipment is available to scientists to simplify the workflow. Proteins of interest can be easily labeled and detected on light-based detection instruments. Immunoassay kits allow you to identify a specific protein of interest and protein detection beads or antibody microarrays allow you to identify multiple specific proteins at once. Protein interactions and enzyme activity can also be monitored with protein-protein interaction assays. Additionally, the biophysical characterization of proteins is made easy with biokinetic analyzers. Find the best protein detection and quantification products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA QuantificationDNA quantification is the process of measuring the amount of DNA in a sample. It is vital in genomics, molecular biology, and biotechnology, helping to ensure accurate experiments and data analysis. Explore DNA quantification tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.RNARNA is a nucleic acid that plays a key role in gene expression and protein synthesis. It serves as a messenger between DNA and ribosomes, carrying genetic instructions to produce proteins. Advances in RNA-based therapies, such as mRNA vaccines and gene editing, have revolutionized treatment strategies for genetic disorders and infectious diseases. Explore RNA research tools and therapies in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.SpectrophotometrySpectrophotometry is a technique used to measure the absorption or transmission of light through a sample. It is commonly used in chemical analysis, environmental monitoring, and quality control. Explore spectrophotometry tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Biotechnica

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