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New Single Quadrupole Mass Spectrometer and Specialized Columns Launched by Thermo Fisher Scientific at HPLC 2017

Thermo Fisher Scientific

Booth P2

18 Jun 2017
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

Thermo Fisher Scientific Inc., the world leader in serving science, today announced new technologies that are designed to allow analytical chemists to obtain high-resolution separations with outstanding sensitivity and reproducibility. Visitors can learn about these and other innovations during HPLC 2017 - The 46th International Symposium on High Performance Liquid Phase Separations and Related Techniques, booth P2 from June 18-22, at the Prague Congress Centre.

“Our customers want to gain a deeper understanding of their samples,” said Mitch Kennedy, vice president and general manager, life sciences business, chromatography and mass spectrometry, Thermo Fisher. “This week at HPLC, we will demonstrate to customers our commitment to innovation and to equipping them with the necessary tools to make their journey from sample to knowledge easier so they can solve their most complex analytical challenges.”

The new Thermo Scientific ISQ EC Single Quadrupole mass spectrometer seamlessly integrates with an existing ion chromatography (IC) or high performance liquid chromatography (HPLC) system and provides excellent small molecule sensitivity and mass confirmation for users. The industry-leading Chromeleon Chromatography Data Software (CDS) platform has embedded ISQ EC MS instrument control, which enables users to minimize time spent on new mass spectrometry (MS) user training. The instrument also provides exceptional robustness, enabling users to analyze a range of simple and complex sample matrices.

Also launching at the show is the new range of Thermo Scientific MAbPac RP 1mm columns, which are designed to provide the resolution and ruggedness required for high-performance, reversed-phase chromatography characterization of monoclonal antibodies, fragments, variants, antibody drug conjugates and proteins. With a 1mm inner diameter, the new columns provide sensitive analyses of very small sample volumes at low flow rates for direct injection into the LC-MS, thus streamlining workflows and achieving high sensitivity. Featuring a polymeric resin with an optimized pore size and thermal and pH stability, the new columns allow consistent and efficient separations with low carry-over.

In addition to the new products on display, Thermo Fisher will host scientific presentations with industry and company experts to highlight the latest developments in chromatography and mass spectrometry. Workshop highlights include:

  • Intact Protein Analysis of Biopharmaceuticals, Monday, 19 June, 12:45-13:45 p.m., room C60. Presented by Ken Cook, Thermo Fisher, and Jonathan Bones, National Institute for Bioprocessing Research and Training (NIBRT), this seminar will explore the latest chromatographic workflows for fast and reproducible characterization of biotherapeutic proteins
  • Enhancements for Improved Routine Impurity Analysis, Tuesday, 20 June, 12:45-13:45 p.m., room E170. Presented by Rainer Bauder, Thermo Fisher, this workshop will look at solutions for efficient, sensitive and reproducible impurity analysis.

For more information, please visit thermofisher.com/hplc2017

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. HPLC Method DevelopmentIt is important to develop and validate HPLC methods in order to identify, quantify or purify compounds of interest in the most efficient way. Effective method development ensures optimization, quality control and cost effectiveness.Triple Quadrupole MsBiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Trace Level ImpuritiesTrace level impurities refer to low concentrations of unwanted substances found in chemicals, pharmaceuticals, and other products. Detecting and removing these impurities is crucial for product safety and regulatory compliance. Explore trace impurity analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Antibody Drug ConjugatesMonoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.Reversed-Phase LC

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