SelectScience
Join Free
NewsLife Sciences

New Range of Flush Solutions Designed to Improve Analytical Instrument Performance

Thermo Fisher Scientific

Thermo Scientific ChromaCare flush solutions and Thermo Scientific UHPLC-MS solvents intend to help prevent protein precipitation for high-quality chromatograms

7 Jun 2018
Holly McHugh
Administrator / Office Personnel

Product news

The Thermo Fisher Scientific product range now includes ChromaCare flush solutions and UHPLC-MS ultrapure solvents(acetonitrile, methanol, water and IPA). ChromaCare reagents are designed to reduce contaminants and prevent protein precipitation. New UHPLC-MS solvents are helping to raise the bar in instrument performance and to maximize productivity across pharmaceutical, biotech, clinical and academic laboratories. Thermo Fisher Scientific showcased these new products during the 66th American Society for Mass Spectrometry (ASMS) Conference, held June 3–7, in the Sapphire Ballroom ABEF at the Hilton San Diego Bayfront, San Diego.

Laboratories could minimize interference and maximize instrument uptime with a novel range of flush solutions for liquid chromatography mass spectrometry (LC-MS) systems and a new line of ultrapure solvents for ultra-high-performance LC-MS (UHPLC-MS) systems.

"Keeping LC-MS instruments performing at the highest standards for optimal laboratory efficiency has been a common challenge for researchers," said Kelly Miller, vice president/general manager, laboratory analytical reagents, Thermo Fisher. "With that in mind, we've developed our new ChromaCare family of flush solutions for use with Thermo Scientific analytical instrumentation, eliminating the need for toxic chlorinated solvents that can degrade seals. When used alongside our new UHPLC-MS solvents, customers can maximize instrument uptime and accelerate their groundbreaking research."

Discover more news like this in our biopharmaceutical special feature >>

Developed for both start-up and upkeep of delicate LC-MS columns and chromatographs, the ChromaCare range includes two new reagents designed to ensure seamless operation of Thermo Scientific LC-MS systems. The LC-MS Instrument Flush Solution reduces background noise, facilitating instrument installation and preventative maintenance routines for optimal performance. The LC-MS Biologics Flush Solution prevents proteins from clogging probes, minimizing instrument downtime and preserving sample integrity.

The new ultrapure solvents can help scientists push the detection limits of UHPLC-MS systems to achieve high-quality separation results by enhancing mass sensitivity and resolution, reducing formation of metal ion adducts and improving peak profiles. The solvents enable optimal signal-to-noise ratio while keeping UV-absorbing and MS-ionizing impurities to a minimum, providing baselines with an extremely low level of background interferences, regardless of the detector used. Because they are ultra-filtered, the solvents are designed to reduce downtime due to clogging of the instrument, columns and check valves, helping to meet the continuous workflow demands of laboratories. Packaged in borosilicate bottles, the solvents also reduce leaching of metal cations to avoid sample contamination.

For all the big news from the show floor visit our ASMS 2018 Special Feature >>

Links

Thermo Fisher ScientificCompany website

Tags

UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. UV-Visible SpectroscopyUltraviolet-visible (UV-Vis) spectrophotometers are used to measure the interaction of UV and visible light with a sample, including transmission, reflectance & absorbance. The two major instrument classes are single-beam or double-beam spectrophotometers. More specialized equipment includes colorimeters, spectroradiometers and refractometers. Portable and microvolume spectrophotometers are also available. For the modular spectroscopy lab, explore a range of light sources for combination with a spectrograph/spectrometer and optics. Find the best UV-Vis spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.ASMSThe American Society for Mass Spectrometry (ASMS) is an organization dedicated to advancing the science and application of mass spectrometry. ASMS supports professionals through events, publications, and research initiatives, promoting innovation in areas like proteomics, metabolomics, and environmental analysis. Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.

Related articles

New Range of Flush Solutions Designed to Improve Analytical Instrument Performance