New Hydrophobic Interaction Column Offers
20 Aug 2014
Many laboratories analyzing monoclonal antibodies (mAb) regularly encounter situations where they need alternative hydrophobic interaction chromatography (HIC) selectivity. Thermo Fisher Scientific has developed new column chemistry that separates many more of these challenging mAbs, antibody-drug conjugates (ADCs) and proteins.
The Thermo Scientific MAbPac HIC-10 HPLC column has been demonstrated to provide selectivity that is different from other commercial HIC columns, including separating many native mAbs, fragments, aggregates, oxidation variants, PEGylated mAbs and ADC.
The column’s proprietary chemistry is designed to provide the new selectivity in a high-resolution column with excellent biocompatibility and high recovery. The column is compatible with organic solvent and aqueous mobile phase. It is designed for rugged stability and very low carry-over.
“MAbs are the most successful and prominent class of biotherapeutics,” said Ilze Birznieks, product line manager, biocolumns, Thermo Fisher Scientific. “HIC is a popular technique for separating these biomolecules, but researchers have been continually asking for alternative selectivity. This new column responds to these customer demands.”
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Thermo Scientific™ MAbPac™ HIC-10 Monoclonal Antibody Column
Thermo Fisher ScientificDesigned for separation of monoclonal antibodies (MAbs) and related biologics by hydrophobic interaction, the Thermo Scientific™ MAbPac™ HIC-10 LC column is a high resolution silica column. The MabPac HIC-10 column's unique chemistry provides high resolution, excellent biocompatibility, and selectivity that is different from other HIC columns on the market. The MAbPac HIC-10 column is based on high-purity, spherical, wide-pore (1,000Å), 5μm silica particles functionalized with proprietary alkyl amide groups. Its advanced surface bonding technology leads to excellent chemical stability, high efficiency, and unique selectivity optimized for MAbs and different from other HIC phases.Features: Excellent biocompatibility and extremely low carryover High resolution and high efficiency Compatible with both organic solvent and aqueous mobile phases Rugged column stability Column Details: Type: Hydrophobic Interaction, Alkyl amide Particle Size: 5 µm Pore Size: 1000 Å Length: 100, 250 mm ID: 4.6 mm