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New HRAM System Makes Orbitrap Technology More Widely Accessible

Thermo Fisher Scientific
12 Mar 2015
Kathryn Rix
Administrator / Office Personnel

Product news

Laboratories performing food and environmental testing, clinical research, forensic toxicology, pharmaceutical/biopharmaceutical measurements and other applied analyses can now benefit from the performance of high-resolution accurate-mass (HRAM) Orbitrap mass spectrometry using a new instrument designed for cost-per-sample-sensitive workflows.

The new Thermo Scientific™ Q Exactive™ Focus LC-MS/MS, exhibited for the first time at Pittcon 2015 at the Ernest N. Morial Convention Center, New Orleans, is designed to make the qualitative and quantitative power of Orbitrap-based instruments available to customers who use quadrupole time-of-flight (Q-TOF) mass spectrometry or comparable mid-tier technologies.

"Many of our customers at applied and small-scale research labs have been telling us they want the combined screening and quantitation capabilities of hybrid mass spectrometry in their labs, where cost per sample and time-to-results really matter," said Ken Miller, vice president, marketing, life sciences mass spectrometry for Thermo Fisher Scientific. "We are pleased to announce that Orbitrap technology has now evolved into the Q Exactive Focus system for this purpose."

"The Q Exactive Focus system is rapidly becoming the gold standard because this single instrument will answer routine quantitative and research analytical demands at an affordable price," said Dr. Bertrand Rochat, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, a Q Exactive Focus early access user.

"I consider the Q Exactive Focus instrument well-suited for pesticide residue analysis," said early access user Dr. Hans Mol, RIKILT Wageninen UR, in the Netherlands. "Besides comparable quantitative data for frequently detected compounds, this instrument provides a complementary screen of many other compounds from the same injection."

The Q Exactive Focus benchtop LC-MS/MS combines high-performance quadrupole precursor ion selection with an HRAM Orbitrap mass analyzer, engineered to provide excellent mass accuracy, sensitivity and fast polarity switching. Extensive testing in company laboratories have shown this instrument to selectively and accurately quantify and confirm analytes with comparable sensitivity to triple quadrupole instruments.

The Q Exactive Focus is designed to deliver up to 70,000 resolution at m/z 200, and scan speed up to 12 Hz. Sub ppm mass accuracy has been achieved routinely in company and early access user laboratories. The instrument is designed for quantitation experiments, with capabilities that include selected ion monitoring (SIM), parallel reaction monitoring (PRM) and data-independent acquisition (DIA).

Full scan confirmation mode and PRM are designed for targeted screening combined with reproducible quantitation results. DIA is intended to provide qualitative coverage for screening unknowns with supporting quantitative data for many of the unknowns identified.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. PittconPittcon is one of the largest conferences and exhibitions dedicated to laboratory science. It brings together professionals and innovators in analytical chemistry, physics, and biology, offering a platform to explore the latest scientific tools and technologies. From cutting-edge laboratory instruments to emerging research trends, Pittcon is a must-attend event for professionals in research and development. Food TestingFood testing refers to a variety experiments including PCR, mass spectrometry, processing, QuEChERS, analyzing and Kjeldahl.Clinical Mass SpectrometryMass spectrometry is emerging as a superior method of analysis over the longstanding, gold standard of immunoassay. Clinical mass spectrometry systems are increasingly accessible to medical laboratories and are capable of providing results with more speed and less expense than traditional methods. From simple mass spectrometers to IVDR class A compliant, highly sophisticated systems performing liquid chromatography tandem mass spectrometry (LC/MS/MS), find the latest product news, reviews and resources to make a purchasing decision for your laboratory. Environmental AnalysisEnvironmental analysis describes a variety of tests that determine the effect of chemicals, processes and particulates such as persistent organic pollutants (POPs) have on the environment.Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.

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