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New Histone Demethylase Antibodies Announced by Novus Biologicals
21 Mar 2011bridget bridget
Laboratory Director
Product news
Novus Biologicals announced today the release of three new rabbit polyclonal antibodies to important histone demethylase proteins: JMJD2C (Catalog# NBP1-49600), JMJD1A (Catalog# NBP1-49601), and JMJD2A (Catalog# NBP1-49602).
All three of these new antibodies cross-react with human and mouse proteins, and are useful for Western blot, immunohistochemistry on paraffin tissues, and fluorescent immunocytochemistry.
JMJD2C and JMJD2A are members of the JHDM3 histone demethylase family. Specifically these proteins demethylate trimethyl 'Lys-9' and 'Lys-36' residues of histone H3, while generating formaldehyde and succinate by-products. JMJD1A is a member of the JHDM2 histone demethylase family, and preferentially demethylates mono- and dimethylated H3 'Lys-9' residue but has weak or no activity on trimethylated H3 'Lys-9'. Together, these three proteins hold an integral role in coding histones with covalent tail modifications, thereby affecting chromatin structure and the subsequent regulation of gene expression.
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