New Bio-Inert 1.8µm Yarra® GFC/SEC Column Delivers Economical Biomolecule Characterization

Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, introduces Yarra 1.8µm SEC-X150 – a high-resolution gel filtration (GFC)/aqueous size-exclusion (SEC) column for the separation of biomolecules on HPLC and UHPLC systems. The proprietary new Yarra surface chemistry, combined with bio-inert column hardware, reduces sample adsorption compared to other GFC/SEC columns currently on the market, providing improved recovery and more accurate quantitation of biomolecules.

With a wide molecular weight range (1 – 450 kDa) and high efficiency, Yarra SEC-X150 columns are well suited for the ultra-high-resolution separation and characterization of proteins and peptides including monoclonal antibodies (mAbs), antibody aggregates, antibody drug conjugates (ADCs), insulin and biosimilars on UHPLC systems.

Because Yarra SEC-X150 columns typically operate at backpressures below 3,500 psi, they can deliver improved performance (greater resolution, better peak shape and faster analysis time) for existing 3µm and 5µm GFC/SEC column methods on HPLC systems. Designed and manufactured for stability, reproducibility and long product life, the new Yarra SEC-X150 and the existing six Yarra 3µm/5µm phases are all supported by an unmatched product quality and performance guarantee.

“GFC/SEC columns currently available from other suppliers are expensive and have left customers frustrated with tedious, solvent- and sample-wasting column priming protocols,” explained Simon Lomas, strategic marketing manager for Phenomenex. “The new Yarra SEC-X150 utilizes greater inertness to overcome sample adsorption while offering an extended molecular range and increased efficiency for better biomolecule characterization, all at an extremely affordable price point.”