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Mechanistic Toxicology Solutions from CXR at SOT 2011

CXR Biosciences Ltd
28 Feb 2011
Sarah Sarah
Marketing / Sales

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Visit CXR Biosciences to learn more about combining innovative and standard mechanism-based approaches to improve compound development or resolve unexpected toxicity issues. The portfolio also includes in vitro & in vivo toxicity biomarkers, screening & investigative toxicology services and novel transgenic animal models (humanized transADMET mice).

CXR Biosciences will work with you in a flexible, consultative and advisory manner to design and interpret state of the art investigative safety studies that deliver the results you need, whilst reducing time, cost and use of animals.

Meet the team; Drs. Cliff Elcombe, Audrey Vardy, Simon Plummer and Jillian McEwan at;

Booth # 1609 at ToxExpo.

Or visit our posters;

Poster #327) THE EFFECTS OF TRIS (2-ETHYLHEXYL) TRIMELLITATE (TOTM) ON GENE EXPRESSION ASSOCIATED WITH TESTICULAR MAL-DEVELOPMENT (TMD) IN RAT FOETAL TESTES
Elcombe, Clifford R1; Dhritiman, Dan1; Farrar, David G2 and Plummer, Simon M1. CXR Biosciences Ltd, Dundee, Scotland, UK1 and INEOS Chlor Limited, Runcorn, UK 2 (Abstract #1048).

Poster #320) IMMUNOHISTOCHEMICAL AND CHIP MICROARRAY ANALYSIS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA (PPAR) IN FETAL RAT TESTES EXPOSED IN UTERO TO DIBUTYLPHTHALATE
Plummer, Simon M1; Dan, Dhritiman1; Quinney, Joanne C1; Millar, Michael3; Hallmark, Nina2; Phillips, Richard D2; Elcombe, Clifford R.1. CXR Biosciences, Dundee, Scotland, UK1, ExxonMobil Petroleum & Chemical, Hermeslaan, Belgium2 and MRC Human Reproductive Sciences Unit, Edinburgh, Scotland, UK (Abstract #1041).

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CXR Biosciences LtdCompany website

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :

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Mechanistic Toxicology Solutions from CXR at SOT 2011