Major Biomedical Research Reagents Supplier Licences Chromatrap ChIP Technology

28 Jun 2017
Abigail Berry
Administrator / Office Personnel

Chromatrap® has announced that BioLegend, a major US-based manufacturer and supplier of reagents and kits for biomedical research, has chosen their novel solid-state ChIP technology to power a new range of faster and more efficient chromatin immunoprecipitation kits.

These new kits will combine BioLegend's expertise in developing the Go-ChIP-Grade™ antibodies that are validated for ChIP assays with the patented solid-state immunocapture surface at the heart of every Chromatrap® product. This combination will result in a market-leading range of ChIP-sequencing kits, offering researchers an opportunity to perform faster, simpler and more sensitive assays for their epigenetics research.

With the rapid growth of ChIP-seq as a technique to interrogate the epigenetic landscape, both companies anticipate this class of kit will meet a critical need in the market.

Product Development Manager for Chromatrap®, Dr Amy Beynon said "The wide distribution network offered by BioLegend is an ideal way to expand the reach of our proven novel solid-state ChIP technology. Access to important geographical markets where BioLegend is an established and trusted supplier forms the core of our relationship. We look forward to supporting many more researchers as BioLegend expands the usage of Chromatrap technology across these markets."

Together the two companies aim to make BioLegend's Go-ChIP-Grade™ antibodies and ChIP kits incorporating Chromatrap technology the method of choice for ChIP-sequencing in the future.

The Chromatrap technology is patented in the USA, Australia, Japan, UK and China by parent company - Porvair. The collaboration with BioLegend covers access to Chromatrap spin columns and proprietary buffers for use in BioLegend's new ChIP-sequencing kits in all geographic territories.

Find further information here.

Chromatrap® Native ChIP Kit

Chromatrap

Chromatrap® Native ChIP kits provide an alternative to traditional cross-linked ChIP, which removes the need for fixing cells prior to extraction. 

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Chromatrap® FFPE ChIP Kit

Chromatrap

Epigenetic identification and targeting in clinical FFPE tissues is a crucial step for potential epigenetic therapeutics and personalized medicine therapies. FFPE is a standard method to archive and preserve medical tissue biopsy samples. These archives, kept in many hospitals world-wide, are a huge, rich and untapped sample resource for genetic research. Due to the cross-linking of proteins by formaldehyde, FFPE tissues present a particular challenge for ChIP analysis. In addition, the small size and delicate nature of the tissue, and the difficulty in extracting samples from paraffin, used to provide tissue support after preservation, can damage complex cellular complexes such as chromatin. ChIP assays from these samples have therefore proved time consuming and difficult.  Chromatrap® FFPE ChIP kit overcomes these issues and provides the following benefits: Provides greater flexibility and more IPs per sample Works across a range of FFPE samples, human and animal Available in 96-well plate or spin column format Works equally well with high and low abundant marks Provides sufficient DNA to perform library preps for ChIP-seq assays

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