SelectScience
Join Free
NewsLife Sciences

LGC becomes first bioanalytical Contract Research Organization to offer HD-X platform in a regulated environment

Resolian
2 Oct 2019
Cameron Smith-Craig
Cameron Smith-Craig
Pharma and Applied Sciences Editor

Product news

LGC has announced the launch of its Quanterix Simoa HD-X automated analyzer, thus becoming the first bioanalytical Contract Research Organization in Europe to offer HD-X platform in a regulated environment.

The HD-X - the very latest fully automated technology platform from Quanterix for developing and performing digital immunoassays – has been unveiled at LGC’s GLP/GCP-accredited lab in Fordham, near Cambridge, UK.

The HD-X builds on the success of the HD-1 analyzer in conveying unprecedented levels of sensitivity, robustness, and throughput to Pharmacokinetic-Pharmacodynamic (PK-PD) bioanalytical studies.

Rachel Green, Operations Director at LGC, said, “The Quanterix HD-X system has enhanced our capability to develop novel, high sensitivity and high throughput immunoassays. The increase in sensitivity that the HD-X offers is between 50-1000 times, compared with other conventional assay platforms – combining this with its automated and multiplexing capabilities, this platform could prove invaluable in helping our customers with early PK/PD decision making, translating into long term efficiencies in their drug development programmes.”

“We are very pleased LGC is moving forward with offering services in a regulated lab on the Simoa HD-X Analyzer, making it possible for their many pharmaceutical company partners to access the ultrasensitive technology. We believe Simoa can dramatically accelerate drug development, delivering insights that can help make drugs less toxic and more efficacious, and is an ideal tool combined with LGC’s industry-leading bioanalytical capabilities,” said Kevin Hrusovsky, CEO and Chairman, Quanterix.

The HD-X offers best-in-class assay PK-PD assay sensitivity and precision through the Quanterix Simoa (Single Molecule Array) technology - a digital form of ELISA, trapping and sealing individual immuno-complexes on paramagnetic beads in thousands of femtolitre sized wells in arrays found on the Simoa Discs. By using this platform LGC is able to offer a range of high-sensitivity commercial biomarker assay kits covering a range of therapeutic areas, alongside bespoke homebrew method development services.

Want more of the latest science news straigh to your inbox? Become a SelectScience member for free today>>

Links

ResolianCompany website

Tags

ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.ImmunoassayImmunoassays are laboratory tests that utilize antibody-antigen interactions to detect specific substances. They are widely used in diagnostics for detecting diseases, drug testing, and environmental monitoring. These assays offer rapid, sensitive, and precise detection of biomarkers, making them invaluable in clinical and research labs. Browse our peer-reviewed product directory to compare immunoassay systems, read user reviews, and get pricing directly from manufacturers.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.

Related articles