High Resolution Separations without Ultra High Pressure
20 Oct 2012Merck Millipore has introduced a new range of Chromolith® HighResolution columns to make high resolution separations easy to carry out. The peak capacity is improved, even though the back-pressure is more than two times lower than any particulate packed column of the same size.
Monolithic silica columns are a single rod of high purity monolithic silica instead of particles. A unique bimodal pore structure gives improved chromatographic performance. This leads mainly to improved separation efficiency and column back-pressure and allows for faster flow rates, reducing the analysis time while enhancing the lifetime of the column.
Benefits of Chromolith® HighResolution include a column performance which corresponds to that of 3 µm particle packed column. They have a separation performance of around 50 percent higher than standard Chromolith® columns. With a back-pressure two times lower than comparable particle packed columns the lifetime of the new columns can be up to 30 percent longer.
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Chromolith® High Resolution HPLC Columns
Merck KGaA, Darmstadt, GermanyChromolith® HighResolution: High resolution separations without ultra high pressure. The revolutionary monolithic Chromolith® HighResolution columns are made from a single rod of high-purity monolithic silica, rather than from particles. Their unique bimodal pore structure allows the chromatographic performance to be improved significantly. Speed of analysis (separations up to 9 times faster if required) Separations two times faster at half the column back-pressure compared to μm columns Higher sample throughput Improved HPLC system security Significantly increased column lifetime Reduced maintenance on HPLC pump and injector seals Reduced need for sample preparation as columns are very resistant to blocking (even with biological samples) Column length no longer pressure limited Very high separation efficiency by column coupling