High Definition Data Directed Analysis: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Untargeted Proteomics Studies

9 Jul 2013
Sarah Thomas
Associate Editor

This application note demonstrates the instrumental and application benefits for the identification of proteins and peptides in a new high definition data directed analysis (HD-DDA) mode, where ion mobility spectrometry is incorporated into a quadrupole time-of-flight mass spectrometer. HD-DDA uses a high duty cycle mode and enhanced decision making to provide a highly sensitive and selective experiment.

SYNAPT G2-Si HDMS

Waters

The Waters SYNAPT G2-Si High Definition Mass Spectrometry provides complete characterization of complex mixtures and molecules with unique levels of MS performance, industry leading informatics and unparalleled platform versatility.Through high-efficiency T-Wave™ ion mobility you can get superior separation, enhance the peak capacity, specificity and sensitivity of your analysis and transform your targeted and untargeted workflows. Ultimate UPLC/MS/MS performance, data independent and data dependant T-Wave IMS solution, CID and ETD fragmentation capabilities and a wide range of experimental options. This system gives you additional dimension of separation, based on molecular size and shape. It delivers a third dimension to your analysis, proven to transform your analytical perspective whatever the application.

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