febit synbio successfully completes synthetic genes pilot project

2 Jul 2007

Product news

Implementing an exceptionally efficacious and cost-effective production technology, febit synbio gmbh is at the verge of entering the synthetic genes market. Geniom, febit´s microarray synthesis and analysis platform which has been successfully established for several years also enables efficient synthesis of high-quality oligonucleotides, the customized building blocks of synthetic genes.

For the first time, febit synbio leverages the innovative advantages of the microfluidic Geniom Biochip for the production of synthetic genes. Since febit provides both device and technique, the design of the synthesizer itself and the process of gene synthesis are seamlessly integrated. Being the leading provider of microfluidic DNA technology, febit has been holding a broad spectrum of US and EU patents since 1999 exclusively allowing febit to exploit biochip technology for the production of synthetic genes.

In cooperation with a large internationally recognized biotechnology company, febit evaluated the market maturity of its synthetic biology technology. The pilot order included 9 synthetic DNA constructs of various lengths and difficulties. The company declared its intention to continue the cooperation.

Peer Stähler, CEO and scientific director of febit synbio gmbh, regards this cooperation as an important step towards the launch of the new product range: "During this joint effort, we greatly expanded our experience, optimizing critical stages in the production process. After successful completion of this challenging initial phase, we are optimistic about evolving our partnership into a long-term customer relationship." Other potential customers have shown their interest in the new technology as well.

febit synbio anticipates marketing its synthetic gene service in fall 2007. During the next months, the company will build up commercial scale production capacities and establish the required sales network.

The Geniom DNA synthesis technology enables biochip-based synthesis of any desired DNA sequence. The resultant oligonucleotides may serve as building blocks for the assembly of synthetic genes and gene clusters or even fully synthetic genomes – providing customized biopart kits for a vast range of applications in synthetic and constructive biology.

Links

Tags

Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
febit synbio successfully completes synthetic genes pilot project