DASGIP® Control is now DASware® control 5

DASGIP bioreactor systems serve as an ideal platform to carry out Design of Experiments (DoE) on bioreactors in parallel. There is a multitude of 3rd party DoE software tools available on the market – DASware design automatically compiles DoE information from such tools into recipes and feedback response information into DoE and multivariate analysis and reporting tools.DASware design comes with a full factorial DoE builder. Alternatively, a large variety of DoE designs for screening, process development and optimization can be automatically imported from the most powerful 3rd party DoE tools like JMP®, MODDE® (Umetrics), Minitab®, and Design-Expert® (Stat-Ease®). Parallel recipes incorporating the DoE factor variations (i.e. pH, DO, temperature set-points or feed rates) are automatically populated. Following DASGIP‘s Point-Click-Grow concept they can be carried out on a set of bioreactors with a single mouse-click. Features: Built-in full factorial DoE: easy definition of experimental factors and responses; center points and randomized positioning of runs Integration of 3rd party DoE tools like JMP and others Recipe generator supporting multiple system layouts Applications: DoE with parallel bioreactor systems such as the DASbox Mini Bioreactor System Screening, process development and optimization

The DASbox is a unique mini bioreactor system suitable for microbial and cell culture as well as stem cell applications. It is designed as a 4-fold system with up to twenty-four parallel operating bioreactors. With working volumes of 60 – 250 mL the DASbox is the optimal tool for advanced process development and Design of Experiments (DoE) applications. All critical process parameters can be precisely controlled. Liquid-free temperature control and exhaust condensation satisfy users with easy handling. In addition to using industry standard glass bioreactors the DASbox can be equipped with Eppendorf BioBLU® 0.3 vessels, all fully instrumented single-use mini bioreactors. Eppendorf DASbox® Mini Bioreactor System Features: Parallel set-up of up to 24 bioreactors; Excellent scalability and reproducibility in both microbial and cell culture applications; Supports industry standard glass bioreactors (DASbox Mini Bioreactor) as well as the BioBLU 0.3 Single-Use Vessels; Small working volumes save on the amount of cell material, media and supplements required; Extremely compact system with a footprint of only 7.5 cm (3 in) benchspace per vessel; Individual temperature control with liquid-free heating and cooling (Peltier); Liquid-free Peltier exhaust condenser with easy handling by automatic slide in activation and slide out deactivation mode; LC display with key process parameters and integrated alarm function simplifies monitoring; Fully mass flow-controlled gas mixing with individual gas mixture from Air, O2, CO2 and N2, each directable either to headspace or sparger; Standard sensors for precise measurement and control of temperature, pH, DO, level and ORP (redox potential); optical pH sensors available; Precise miniature variable speed pumps, continuous flow rates down to 0.3 mL/h; Sealed magnetic overhead drives for single-use vessels and direct overhead drives for autoclavable vessels; up- or downflow selectable; Optional pull-out system for enhanced accessibility of bioreactors and control unit. Applications: Process development in cell culture and microbiology; Design of Experiments (DoE) Media optimization Clone and cell line screening, strain characterization.