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Bruker BioSpin Introduces the Avance™ III, the Fastest, Highest Performance and Most Flexible NMR Spectrometer Ever

1 Mar 2009

Product news

At Pittcon 2007, Bruker BioSpin announced the introduction of its novel Avance III NMR (Nuclear Magnetic Resonance) spectrometer. With the further enhanced Avance III NMR spectrometer architecture, Bruker BioSpin introduces the fastest, highest performance and most flexible NMR spectrometer on the market today. The Avance III architecture is based on a forward-thinking electronics concept with an unprecedented level of digital control, exceptionally pure NMR frequency generation and unmatched speed and flexibility.

Avance III systems have already successfully been placed in all Bruker BioSpin applications and demonstration laboratories worldwide. The Avance III also has gone through very rigorous and extended customer testing and validation, and has received an enthusiastic customer reception. It is available for immediate delivery for all NMR applications and NMR frequencies from 300 up to 950 MHz.

The Avance III is the next generation in the very successful Avance product line, which has established Bruker BioSpin as the clear global technology and market leader in NMR and pre-clinical MRI. The Avance III spectrometer is designed around an advanced digital concept that provides an optimized pathway for highest speed RF generation and data acquisition with a highly modular and scalable transmitter and receiver channel architecture.

The Avance III features the most advanced RF generation in the industry, a unique digital lock for superb experimental stability, and second-generation digital receiver (2G-DR) technology for high dynamic range, high digital resolution and large bandwidth digital filtering. The result is the extremely fast Avance III spectrometer with 25 ns event timing (12.5 ns clock), including simultaneous phase, frequency and amplitude switching, and unsurpassed RF performance, enabling even the most demanding new solid-state NMR experiments.

Together with a wealth of performance-leading CryoProbes™ and other advanced liquids, solids and imaging NMR probe choices, and a broad array of automation and hyphenation options, the Avance III is the NMR spectrometer that will enable not just the latest, but also future experiments and research applications. Bruker BioSpin already offers the most advanced UltraShield™ NMR magnets in the industry. Easy upgradeability through software updates, improved remote service and support, and established multiple-receiver operation are just a few of the benefits of the newest Avance III architecture.

The Avance III is operated via the popular TopSpin™ software that enables easy access to the power of the spectrometer for both routine industrial, walk-up or automation customers, as well as for cutting-edge NMR structural biologists and solid-state researchers.

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NMR and EPR SpectroscopyNuclear magnetic resonance (NMR) spectroscopy is used to resolve the local chemical environment of atomic nuclei with spin, revealing information on molecular structure, dynamic processes and chemical reactions of organic molecules, from proteins to synthetics. Electron paramagnetic resonance (EPR) also known as electron spin resonance (ESR) spectroscopy is used to detect and quantify paramagnetic species in a sample, including free radicals as transition metal ions. By immersing the sample in a strong magnetic field, both NMR and EPR spectrometers probe the sample with either radio waves or microwaves respectively. A range of benchtop, solid-state and time domain NMR spectrometers & EPR spectrometers are available, as well as NMR tubes, NMR solvents, software, coils, and magnets. Find the best NMR & EPR equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.

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Bruker BioSpin Introduces the Avance™ III, the Fastest, Highest Performance and Most Flexible NMR Spectrometer Ever