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Applied Biosystems/MDS Analytical Technologies Launches New Mass Spectrometer to Accelerate Proteomics Research

Thermo Fisher Scientific
6 Apr 2009
Samantha Rosoman
Campaign Coordinator

Product news

Applied Biosystems, a division of Life Technologies, and its mass spectrometry joint-venture partner, MDS Analytical Technologies, a business unit of MDS Inc., today introduced the AB SCIEX TOF/TOF(TM) 5800 System, the fastest, most sensitive MALDI-based mass spectrometer ever built. This system, which is now commercially available, will help researchers advance the discovery of biomarkers to improve the understanding of diseases for potential use in a clinical setting, which is part of the promise of personalized medicine.

The AB SCIEX 5800 System represents a significant advancement in MALDI-TOF mass spectrometry (matrix-assisted laser desorption/ionization time-of-flight technology), which works by ionizing complex biological samples and identifying the individual protein components by their molecular weight. This system enables researchers to identify up to 30% more proteins at a rate that is 10 times faster than any other MALDI system on the market, thereby setting the highest standard for protein biomarker discovery, MALDI imaging and protein identification. This system, combined with the release of a new processing software application, ProteinPilot(TM) 3.0, is part of a complete workflow that accelerates proteomics research.

By expanding the boundaries of protein discovery, the AB SCIEX 5800 System enables scientists to achieve in less than a day what takes more than two weeks on other MALDI-based systems. This system is expected to advance the discovery of new biomarkers that could potentially yield more accurate and sensitive clinical tests in the future, which is a high priority in the medical and scientific communities. The AB SCIEX 5800 System enables the discovery of a wider range of protein biomarkers, enabling scientists to identify and quantify more proteins in complex samples faster than existing systems today.

Laura Lauman, President of Life Technologies Mass Spectrometry Systems Division

"The ability to better understand diseases at the protein level will ultimately improve diagnosis and help to create more effective treatments based on an individual's expression of specific proteins that relate to a disease or a response to targeted therapies. The AB SCIEX 5800 System delivers innovative, breakthrough technology that provides a giant technological leap forward that will help translate today's biomarker research into tomorrow's personalized medicine."

Andy Boorn, President of MDS Analytical Technologies

"We have developed the most advanced MALDI mass spectrometer ever built. The AB SCIEX 5800 System is another example of how Applied Biosystems/MDS Analytical Technologies continues to innovate and develop best-in-class instrument systems that form the backbone for complete workflow solutions for biomarker and protein research. This is essential technology for researchers to expand their protein studies."

Mark Stolowitz, Ph.D., Director of the Proteomics Core Facility at the Canary Center for the Early Detection of Cancer at Stanford University's School of Medicine

"Mass spectrometry will play a significant role in our efforts at our new center for cancer research in discovery and verification of protein biomarkers, contributing to the realization of personalized medicine, which is closer than many people may think. We chose the AB SCIEX 5800 System as our facility's first proteomics platform because it enables the breadth of applications we need to hit the ground running. We will use its unique capabilities to address the gap between biomarker discovery and clinical immunoassay to ultimately impact patient care."

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :

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