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Analytical Technologies to Characterize and Understand Cancer Metabolism

Waters

Waters to showcase the technology advancing cancer research at AACR 2018

4 Apr 2018
Sarah Thomas
Associate Editor

Product news

At this year's AACR annual meeting in Chicago, Illinois, Waters Corporation will be showcasing a number of innovative analytical technologies that biomedical researchers need to characterize and better understand cancer metabolism. In booth #1242, the company will provide details about their analytical solutions for omics discovery, biomarker translation, molecular visualization and the analysis of antibody drug conjugates.

In addition to the booth, Waters would like to call your attention to 5 posters which leverage the power of MS to advance cancer research:

  • Poster #4109 / 10 - Multi-modality imaging to interrogate lipidome changes during melanoma progression in zebrafish. E. Jones, Waters Corp., Wilmslow, UK and D. Foster, Univ. of Manchester, Manchester, UK
  • Poster #4118 / 19 - Rapid, non-subjective characterization of disease in preclinical cancer research using desorption electrospray ionization mass spectrometry. Arash Zarrine-Afsar and M. Woolman, University Health Network, Toronto, ON, Canada
  • Poster #3998 / 2 - Integrative molecular analysis uncovers key molecules and signaling pathways regulated by RKIP in gastrointestinal stromal tumors (GISTs). N. C. Campanella, Sr., Barretos Cancer Hosp., BARRETOS, Brazil
  • Poster #5654 / 10 - Fully automated tissue classification by imaging mass spectrometry, moving towards a hundred samples a day. E. Jones, Waters Corp., Wilmslow, UK
  • Poster #5661 / 17 - A multi modal mass spectrometry imaging strategy to profile the metabolic hallmarks of colorectal cancer. J. Bunch, Natl. Physical Lab., Teddington, London, UK

Also, don’t miss the 'Oncology Biomarker Detection, Characterization, and Quantification by Mass Spectrometry' workshop on Saturday April 14, 2018, 8:00 AM - 10:00 AM in Room S405 - McCormick Place South (Level 4). The workshop, chaired by Ahmed M. Aman of the Ontario Institute for Cancer Research, will cover recent advancement in mass spectrometric (MS) techniques from sampling to detection and improvements in data analysis procedures, computational tools and methodologies to enable novel approaches to cancer biomarker discovery.

Waters’ Molecular Visualization tools measure spatial distribution of molecules, without labeled probes that can maximize information from a single tissue sample to compare cell morphology and/or drug metabolite distribution. They will also feature protein and metabolite biomarker verification and validation tools that can accelerate cancer research and minimize analytical variability for consistent, reproducible results that can accelerate decision timelines.

Click here to visit their event page >

Links

WatersCompany website

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.AACRThe American Association for Cancer Research (AACR) is a leading organization focused on cancer research and treatment. It provides a platform for scientists, healthcare professionals, and industry leaders to share knowledge and collaborate in the fight against cancer.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.

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