Agencourt<sup>®</sup> DNAdvance System Delivers High DNA Recovery From Mammalian Tissue Samples

4 Aug 2008

Product news

Beckman Coulter, Inc. introduces the Agencourt® DNAdvance System, a new extraction kit for DNA isolation and purification from mammalian tissue samples. The new system delivers a combination of recovery, yield and purity not available with any other kit on the market today. It incorporates the patented SPRI® (Solid Phase Reversible Immobilization) paramagnetic bead-based nucleic acid purification technology. The Agencourt DNAdvance chemistry is automated on the Beckman Coulter Biomek® NXP and FXP Laboratory Automation Workstations to process three 96-well plates in about 75 minutes without the use of organic solvents, vacuum filtration or centrifugation. Full walkaway automation can be easily achieved with a PlateStak* Automated microplate handler that enables continuous throughput.

The Rutgers University Bionomics Research and Technology Center (BRTC) is a Beta site for this new extraction system. Already a user of Beckman Coulter's Biomek Laboratory Automation Workstations, the BRTC easily automated the Agencourt DNAdvance chemistry.

"We're seeing a higher success rate for extractions with Agencourt DNAdvance and the bead-based technology gives us more consistent results," commented Dr. Andrew Brooks, Director of the BRTC. "By automating the chemistry on the Biomek FXP we are experiencing faster processing that helps us meet our aggressive goals."

"Many projects are using knock-out mice for genotyping studies but DNA extraction from a mouse tail can be difficult," explained Todd Lombardo, senior product manager for Agencourt. "The Agencourt DNAdvance System provides a streamlined extraction process that delivers maximum yields for these applications."

Agencourt Bioscience Corporation, a wholly owned subsidiary of Beckman Coulter, is a leading provider of nucleic acid purification products and genomic services for life science research.

DNAdvance is for research use only; not for diagnostic use.
*PlateStak is registered trademark of PerkinElmer, Inc.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Robotic WorkstationsRobotic workstations are automated platforms enabling the user to perform high-throughput, multi-application processes, from sample preparation tasks such as PCR set-up, DNA purification and NGS library preparation, to integrated sample prep and analysis workstations. Automation makes processes consistent, fast, precise and fully walk-away. Find the best robotic workstations in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.
Agencourt<sup>®</sup> DNAdvance System Delivers High DNA Recovery From Mammalian Tissue Samples