Application Note: Thermal Stability Buffer Screening of Therapeutic Antibodies
22 February 2017

Therapeutic antibodies require optimal formulations to ensure long-term stability and, in the drug development process, the thermal stability of the antibody in a range of buffer formulations is routinely tested. This application note presents a label-free DSF (differential scanning fluorimetry) technique using the NanoTemper Prometheus NT.48 as a method for screening therapeutic antibody buffers. The Prometheus NT.48 can quickly obtain high-quality thermal unfolding data for antibodies over a large range of antibody concentrations.

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