Simultaneous Quantitative and Qualitative Analysis of Proteolytic Digests of Therapeutic Monoclonal Antibodies using a TripleTOF® System
24 Jul 2013In recent years MS has emerged as a superior method for characterizing the heterogeneity of monoclonal antibodies. This application note presents a high-speed LC/MS/MS method for the analysis of enzymatically digested therapeutic antibodies. Sophisticated software tools, that enable more accurate peptide mapping, are also described.
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