Application Note: NaV1.5-ΔKPQ late INa current properties and pharmacology on the SyncroPatch 384i
19 August 2020

Here Nanion Technologies GmbH, presents data collected on the Syncro- Patch 384i showing the peak and late INa current recorded from WT and NaV1.5-ΔKPQ cell lines. Peak current could be reliably recorded from both cell types. In WT cells, late INa was negligible in the absence of ATX-II, whereas the late INa from NaV1.5-ΔKPQ cells could be reliably recorded. Peak current from WT, and peak and late INa from NaV1.5-ΔKPQ was inhibited by ranolazine and mexiletine and IC50 values agreed well with the literature6.