Scientific Poster: Comparison of Assay Methods for the Detection of Residual Protein A in Biological Therapeutics
7 April 2015

Protein A has been shown to leach from columns during purification of antibodies resulting in contamination. This poster provides a comparison of several suitable detection methods for the presence of residual Protein A in therapeutic biological agents including a homogenous proximity assay and conventional ELISA assay. The comparison includes evaluation of the lower detection limit of Protein A as well as screening results for detection of residual Protein A in a panel of nine human IgG antibodies.