Structure-based drug discovery with cryo-EM
7 Oct 2019Cryo-electron microscopy (cryo-EM) is a powerful biophysical technique that allows researchers to visualize molecular assemblies at near-atomic resolution. In this application-based eBook, we outline the application of cryo-EM in structure-based drug discovery and look at how state-of-the-art microscopes, such as the Krios G4 cryo-TEM from Thermo Fisher Scientific, help to keep leaders in the pharmaceutical industry at the forefront of drug discovery.
Download this eBook to learn more about:
- The single-particle analysis (SPA) workflow
- Micro-electron diffraction (microED) using nanocrystals
- The applications of cryo-EM in structure-based drug design
- Scientists who are using this technique, including Nobel laureate Dr. Richard Henderson
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Glacios™ Cryo-TEM for Life Sciences
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Krios G4 Cryo-TEM for Life Sciences
Thermo Fisher ScientificThe Thermo Scientific Krios G4 Cryo-Transmission Electron Microscope (Cryo-TEM) is a compact TEM. The instrument can be installed in labs with a ceiling height below 3.04 m (~10 ft), as the microscope height it below 3 meters. The Krios G4 Cryo-TEM has improved ergonomics for easier sample exchange. Data acquisition set up is easier and faster thanks to enhanced automation, systematic user guidance and advanced performance monitoring. Simultaneo