Application Note: High-Throughput Phenotypic Screening Workflow for Cytotoxic Determination
19 January 2018
In the following application note, TTP Labtech discusses a workflow for small-molecule library screens for phenotypic assays. TTP employs a workflow that encompasses the comPOUND and comPILER to select a targeted library of compounds, the dragonfly discovery for reagent dispersal in 1,536 well plates and finally, the acumen cellista for whole well imaging and phenotypic screening data collection. HeLa cell response to well-characterized anti-cancer agents was monitored to evaluate the efficiency and sensitivity of this system.