Application Note: Characterization of High Concentration Protein Solutions with the pUNk
4 January 2018
Dynamic light scattering (DLS) is widely used to detect the size and distribution of molecules, particles and their aggregates under a variety of solvent conditions. In the field of protein crystallography, the process of increasing the concentration of protein solutions required for crystallization often encourages unwanted aggregation. However, some DLS systems are incapable of detecting these aggregates due to excessive light scattering from the concentrated sample.