Application Note: LINE-1 global methylation analysis
8 March 2021

As LINE-1 constitutes approximately 17% of the human genome, the extent of LINE-1 methylation is regarded as a surrogate marker of global DNA methylation.

In this application note, EpigenDx demonstrate the use of LINE-1 methylation levels as an excellent pharmacodynamic (PD) marker for hypomethylating agent therapy.