Anti-Tyrosine Hydroxylase Antibody
Tyrosine hydroxylase (also know as Tyrosine 3-hydroxylase and Tyrosine 3-monooxygenase) plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.
Product Details
- Cat. No.
- AB152
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Reviews
A specific antibody, works well!
Immunofluorescence
The antibody works well without any unspecific signal, with a strong signal covering all the structure of dopaminergic neurons. I've used the antibody in incubation for 3 days at 4 degrees in normal donkey serum, bovine serum albumin, and 0.1% Triton-X100 to stain organotypic brain cultures of the substantia nigra. The secondary antibodies was an AlexaFluor 546 (red). No differences were observed in different lots of the antibody.
Review Date: 4 Dec 2018 | Merck KGaA, Darmstadt, Germany
Applications
- ELISA (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
- Immunoprecipitation (IP)
- Western Blotting (WB)
Antibody Overview
About the company
Merck KGaA, Darmstadt, Germany
Merck, a leading science and technology company, operates across healthcare, life science and performance materials. Around 57,000 employees work to make a positive difference to millions of people’s lives every day by creating more joyful and sustainable ways to live. From advancing gene editing technologies and discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2019, Merck generated sales of €16.2 billion in 66 countries.