Description

IL-22 monoclonal antibody (1H8PWSR) reacts with mouse interleukin(IL)-22, a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17, NK cells, and some other T cells. In in vitro Th17 cultures, induction of IL-22 expression is greater in response to IL-23 than IL-6 or TGF-β, suggesting that this cytokine may be secreted by more fully differentiated Th17 cells in vivo. A heterodimer consisting of IL-10R2 and IL-22R1 serves as the receptor for IL-22. Th17-secreted IL-22 binds to the IL-22 receptor complex on target cells to induce the expression of anti-microbial peptides β-defensin-2 and β-defensin-3. Recently, it was demonstrated that IL-22 is able to protect hosts against bacterial infections of the lungs and gut. This IL-22 monoclonal antibody (1H8PWSR) is labeled with PerCP-eFluor 710, which excites at 488 nm using a blue laser and emits at 710 nm. It has been tested in flow cytometry applications.

Biological Information