Fast Molecular Interaction Screening of Epigenetic Gene Regulator G9a with Fragments from a Large Chemical Space
12 February 2019

Dianthus swiftly detects and quantifies molecular interactions in solution, independent of the molecular mass of the two interacting molecules, making it a perfect match for fragment-based screening with compounds representing a large chemical space. In this application note,  data from single-dose screening of a fragment library is shown with a broad molecular mass and complexity range against the target molecule histone methyltransferase (HMT) G9a, followed by affinity constant determination (Kd) for a selection of hit molecules. 


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NanoTemper Technologies Present Dianthus12 Feb 2019