SelectScience InterviewsLife Sciences

Multiplex-Enabled Biomarker Analysis for Improved Monitoring of Lupus Nephritis

27 Nov 2018
Multiplex-Enabled Biomarker Analysis for Improved Monitoring of Lupus Nephritis

Lupus nephritis is an autoimmune condition affecting kidney function in both children and adults. Dr. Eve Smith, a NIHR Clinical Lecturer based at Alder Hey Children’s Hospital in Liverpool, UK discusses the difficulty clinicians have when monitoring the disease using traditional methods in the clinic, and how research into urine biomarker combinations using customized MILLIPLEX® Multiplex Assays powered by Luminex® xMAP technology, helps to save time, cost and amount of sample required to enable better monitoring of the condition.

MILLIPLEX MAP Human Complement Panel 1 - Immunology Multiplex Assay

Merck

EMD Millipore’s MILLIPLEX® MAP Complement Panel 1 Magnetic Bead Panel is an 8-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma or culture supernatant samples: Complement 2, Complement C4B, Complement C5, Complement C5a, Complement C9, Adipson/Complement Factor D, Mannose-Binding Lecting (MBL) and Complement Factor I. MILLIPLEX® MAP offers the broadest selection of analytes across a wide range of disease states and species. Once the analytes of interest have been identified, you can rely on the quality that we build into each kit to produce results you can trust. In addition to the assay characteristics listed in the protocol, other performance criteria evaluated during the validation process include: cross-reactivity, dilution linearity, kit stability, and sample behavior(e.g. detectability and stability). Each panel and kit meets stringent manufacturing criteria to ensure batch-to-batch reproducibility. Each MILLIPLEX® MAP panel and kit includes: Quality controls (QCs) provided to qualify assay performance Comparison of standard (calibrator) and QC lots to a reference lot to ensure lot-to-lot consistency Optimized serum matrix to mimic native analyte environment Detection antibody cocktails designed to yield consistent analyte profiles within panel EMD Millipore’s MILLIPLEX® MAP Complement Panel 1 Magnetic Bead Panel is part of the most versatile system available for complement factor research. From our single to multiplex biomarker solutions, we partner with you to design, develop, analytically validate and build the most comprehensive library available for protein detection and quantitation.

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Multiplex-Enabled Biomarker Analysis for Improved Monitoring of Lupus Nephritis