Exploring Spatial Interactomics for Deeper Insights into the Tumor Microenvironment

Protein-protein interactions (PPIs) are essential for the performance of cellular functions and biological processes. The Naveni^® in situ proximity ligation technology pushes the boundaries of fluorescence-based in situ methodology, enabling researchers to get the maximum information from every analysis by visualizing and quantifying proteins, their interactions and modifications, in situ at the molecular level. This innovative approach allows researchers to study even low-abundant proteins without altering the cell's natural environment, contributing to a deeper understanding of biological mechanisms in tissues, drug responses, and cellular microenvironments.

In this webinar, Dr. Doroteya Raykova, Application Scientist at Navinci Diagnostics, will discuss the latest advancements in proximity ligation-based technology that allow for highly sensitive and specific visualization of free and interacting proteins. Additionally, Dr. Carlo Bifulco, Chief Medical Officer at Providence Genomics will show real-world case studies highlighting how to go beyond conventional spatial biology and illuminate function with spatial proteomics.

Key learning objectives

• Explore the potential of in situ proximity-based protein detection in pre-clinical and clinical research, focusing on immune checkpoints like PDL1-PD1
• Learn how proximity-based technology enables precise biomarkers and their application across protein research stages, from discovery to clinical use
• Discover how in situ proximity ligation technology goes beyond immunohistochemistry and even traditional spatial multiplexing techniques to illuminate protein function

Who should attend?

• Researchers
• Principal investigators
• Professors
• Post-doctoral researchers

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.