Scalable chromatographic clarification platform for mAb manufacturing in CHO systems

As CHO-based processes for recombinant proteins continue to have increased cell densities and titers, the need for advancement in clarification technologies is of importance to enable manufacturing scalability. A novel technology, anion exchange (AEX) fiber chromatography, aims to address this challenge and has proven to be scalable up to large commercial manufacturing. This approach combines the ease of filter-like flowthrough operation and scalability, as well as the separation precision of chromatography.

Join Dr. Masa Nakamura, Senior Application Development Specialist, Solventum, as he showcases a new clarification platform strategy that can offer seamless implementation and deployment from discovery to clinical and commercial manufacturing. It can also provide consistent and high-quality clarified fluid to enhance commercialization productivity.

Key learning objectives

• Learn about the application of synthetic fiber chromatography to the clarification unit operation
• Explore a novel approach to harvest and clarification in CHO processes
• Understand options to overcome scale up challenges and to reduce soluble impurities during clarification

Who should attend?

• Scientists, Engineers, and Heads of process development, manufacturing, MSAT, and CMC from biopharmaceutical organizations focused on recombinant protein production in CHO expression systems.

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes