Simplifying spectra with middle-down characterization of antibodies and ADCs
Wednesday, October 29, at 16:00 GMT | 17:00 CET | 12:00 EDT | 9:00 PDT
Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are pivotal in disease treatment. These innovative therapies have revolutionized the way we approach complex diseases, offering targeted and effective treatment options.
Join our expert speakers as they delve into the intricacies of how middle-down mass spectrometry (MD MS) with proton transfer charge reduction (PTCR) simplifies spectra for precise analysis, making it easier for scientists to obtain accurate and reliable data.
Plus, discover how the Thermo Scientific™ Orbitrap™ Ascend Tribrid™ Biopharma mass spectrometer and PTCR enhance mAb and ADC characterization for better biotherapeutic development. Key benefits include improved accuracy, fewer false positives, and efficient characterization.
Key learning objectives:
- Learn new approaches to accurately characterize the drug-to-antibody ratio (DAR), drug load distribution, and the exact sites of conjugation of ADCs
- Discover how PTCR can be leveraged to further enhance drug characterization using middle-down mass spectrometry (MD MS)
- Understand how to safely and accurately accelerate your drug to market
Who should attend?
Researchers, scientists, and regulatory professionals specifically working with monoclonal antibodies and antibody-drug conjugates.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
Speakers
Dr. Luca Fornelli earned both his B.Sc. and M.Sc. in Biotechnology from the University of Padova, Italy. He received his PhD under the supervision of Dr. Yury Tsybin at the École Polytechnique Fédérale de Lausanne, Switzerland, with a thesis focused on the characterization of antibodies by middle-down and top-down mass spectrometry. He later obtained a postdoctoral fellowship from the Swiss National Science Foundation and joined the research group of Dr. Neil Kelleher at Northwestern University. Since 2019 Dr. Fornelli works as an Assistant Professor at the University of Oklahoma, where he develops new methods for top-down proteomics.
Dr. Kristina Srzentić earned both her B.Sc. and M.Sc. in Chemical Engineering and Applied Chemistry from the University of Zagreb, Croatia. She received her PhD under the supervision of Dr. Yury Tsybin at the École Polytechnique Fédérale de Lausanne, Switzerland, after which she joined the research group of Dr. Neil Kelleher at Northwestern University as postdoctoral associate. In 2018, she joined Thermo Fisher Scientific where she works as an Applications Development Manager in BioPharma VM group and as a Product Manager for Direct Mass Technology.
Moderator
