Exploring a novel target in therapeutic chemistry with CETSA
27 Nov 2024Jonathan Ellery, Director of Biology at Sitryx, shares his experience of using CETSA® from Pelago Bioscience, to investigate a new target with established chemistry. CETSA proved useful in addressing concerns about the compound's effectiveness in tissues by confirming the compound's binding and stabilization of the target, while providing insights on target engagement.
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Target Deconvolution with CETSA
Pelago BioscienceTarget Deconvolution service based on proteome-wide Cellular Thermal Shift Assay using Mass Spectrometry detection is performed in intact cells and lysate without any compound modifications.
Primary Screening with CETSA
Pelago BiosciencePrimary screening based on Cellular Thermal Shift Assay (CETSA) allows for rapid identification of high quality chemical starting points against the native, full-length protein in live cells.
Hit confirmation with CETSA
Pelago BioscienceHit confirmation service is based on the Cellular Thermal Shift Assay (CETSA) and allows for assessment of compound binding to a selected target protein in its native state without any modifications to the protein or the compound.
