Top List: Most Read Articles of 2015

Have you read them all?

12 Jan 2016

Have you read them all?

2015 was an exciting year for SelectScience® – we unveiled our brand new website in March and held the hugely successful Scientists’ Choice Awards®, including the first Reviewers’ Choice Award. From liquid biopsies and ground-breaking drug discovery, it was also a big year for scientific research. Read on for our count-down of the 10 most read articles on in 2015.


10. Webinar Highlights: Strategies for the Separation and Characterization of Protein Biopharmaceuticals 

Protein biopharmaceuticals are being developed at an explosive rate and have attracted great interest from both smaller biotech firms and big pharma. From an analytical perspective, handling biomolecules presents new challenges for chromatographers, and the field of bio-chromatography is advancing rapidly as new and higher resolution techniques for characterizing proteins are evaluated and better understood. In this webinar, Dr Koen Sandra, of the Research Institute for Chromatography discussed the recent analytical work his team have done to evaluate both innovator biopharmaceuticals and biosimilars. Read the highlights from the webinar Q&A session or watch the webinar on-demand here.


9. Revolutionary Open-Access Laboratory Facilitating Innovative Research

At the University of Southampton, UK, Dr John Langley, Associate Professor in Mass Spectrometry, has to keep his lab at the forefront of separation science. In this exclusive interview, he explained why he made the change from HPLC to UPLC, and how open access analysis has improved research. 


8. The Advantages of Reaction Monitoring by NMR at Pfizer

NMR has been a standard analytical technique in academia for many years, enabling scientists to confidently understand reactions at a molecular level.  But while reaction monitoring is a traditional technique, it has significantly gained popularity in the pharmaceutical industry due to initiatives such as process analytical technology (PAT). SelectScience spoke to David Foley, Principal Scientist at Pfizer, about how he uses NMR to enable reaction understanding in the pharmaceutical industry.


7. Detecting Autologous Blood Transfusion with Clinical Biomarkers

Blood doping refers to the methods, such as autologous blood transfusion, used by athletes to increase the amount of oxygen in their blood stream, leading to enhanced performance. However, legitimate autologous transfusion is also used by patients awaiting elective surgical procedures as a way of reducing the risks associated with receiving blood from someone else. Nicolas Leuenberger, Certifying Scientist at The Swiss Laboratory for Doping Analyses (LAD), a WADA-accredited lab in Lausanne, Switzerland, spoke to SelectScience on a research study on methods of identifying illicit use of autologous transfusions. 


6. New Infectious Disease Assay Could Improve Patient Management and Reduce Antibiotic Resistance

MeMed recently announced publication of the results of a large multicenter prospective clinical study that validates the ability of its ImmunoXpert™ in vitro diagnostic blood test to determine whether a patient has an acute bacterial or viral infection. Sonia Nicholas, SelectScience's Clinical Editor, spoke to MeMed co-founder, Eran Eden, to find out more


5. The Changing Face of the Clinical Microbiology Lab: Introducing IRIDICA

If there is one area of infectious disease diagnostic science that has been largely overlooked in recent decades, then it has to be clinical microbiology. Blood culture and manual processing still reign in many microbiology labs around the world. However, the modern diagnostic era is ushering in a new age for infectious disease laboratories. SelectScience spoke to Dr Rangarajan Sampath, Senior Director of R&D, Ibis Biosciences, Abbott, about IRIDICA, the new infectious disease diagnostics platform from Abbott. 


4. Steve Rees, of AstraZeneca, Discusses Cutting-edge Technologies for Drug Target Validation      

As the Vice-President of Screening Sciences and Sample Management at AstraZeneca, Steve Rees has global responsibility for Compound Management, the human tissue Biobank and High Throughput Screening. He spoke to SelectScience’s Editor-in-Chief, Kerry Parker, about the industry’s approach to target validation and the current challenges and opportunities for new technology.


3. My Lab Essentials: ‘The Swimming Professor’ Andreas Fath

My Lab Essentials, the ‘Swimming Professor’, Prof Dr Andreas Fath, from the University of Furtwangen, Germany, spoke to SelectScience about his novel research into the electrochemical degradation of water contaminants and the equipment that is vital to his work. You can also read the rest of our My Lab Essentials series here.


2. Parts 1 and 2: MALDI-TOF and the Clinical Microbiology Laboratory

SelectScience spoke to Dr. Robert Jerris, Director of Clinical Microbiology at the Children’s Healthcare of Atlanta Pediatric Hospital, who discussed his experiences in implementing and using the MALDI Biotyper for clinical diagnostics use. In part one of this interview, Dr Jerris explained how this technology is a ‘game changer’ for the clinical laboratory, revolutionizing the microbiology lab and enhancing patient care. In part two, Dr Jerris talked about the challenges and hurdles of integrating MALDI-TOF, and its impact on patient care. 


And finally, our most read article of 2015 is….


1. Early Detection of Ovarian Cancer: Medical University of Vienna Demonstrates ANGLE’s ‘Blood Biopsy’ Technology

Researchers from the Medical University of Vienna presented a scientific poster at the American Association of Cancer Research Annual meeting, detailing a protocol combining the novel microfluidic Parsortix™ technology with qPCR, enabling molecular analysis of circulating tumor cells (CTCs) implicated in ovarian and breast cancer and allowing the implementation of ‘liquid biopsies’ in cancer detection studies and as a companion diagnostic in clinical trials. Prof. Robert Zeillinger, Head of the Molecular Oncology Group, Medical University of Vienna, met Kerry Parker of SelectScience to explain more.


Look out for more exclusive interviews and articles from our expert editors coming in 2016!