This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara). Ppara Knockout Rat Characteristics: Homozygous Knockouts exhibit complete loss of protein via Western blot Background Strain: Sprague-Dawley Research Applications: Lipid metabolism Diabetes Obesity Cell proliferation Wound healing Inflammation/Autoimmune disorders
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson’s disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.Pink1 (Park6) Knockout Rat Characterist…
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.Disc1 Knockout Rat Characteristics: Disc1 is involved in neuronal growth and cortical development The protein also regulates the pro…
This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger’s syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders.Neuroligin 3 (Nlgn3) Knockout Rat Characteristics: This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization…
This model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lin…
Colony Expansion and Custom Breeding Services SAGE® Labs offers continued support for your custom model generation needs. Whether it’s breeding a small cohort of homozygous knockouts for characterization or expansion for regular cohort delivery, our expert staff will work with you to determine the best breeding plan to meet your research goals.Features: Specific pathogen-free facility Comprehensive health monitoring pro…
Envirotainer presents the latest addition to our portfolio of active temperature-controlled air cargo containers. Designed for the most extreme requirements of the healthcare industry, the RAP e2 container maintains product temperatures between ±0 and +25°C in nearly any ambient condition appearing along shipping routes globally.The container handles any chosen set temperature, including the most commonly required in the cold…
Drawing on the benefits of the shape and size of the Envirotainer dry-ice container, the RKN e1 uses a different technology: compressor cooling and electric heating. Designed for the extreme requirements of the healthcare industry, the RKN e1 container maintains product temperatures in the +2 to +8°C range, in the controlled room temperature (+15 to +25 °C) range or at any chosen set temperature within the operating range of…
Get started in healthcare transports or share knowledge and become better at what you do. A dedicated team of specialists is there to provide you with solutions and services that strengthen and extend your business. Envirotainer provides valuable additional services, including laboratory testing, qualification and validation support, data collection and reporting services, and the Qualified Envirotainer Program (QEP)…
Your product development plans deserve the best integrated program of research services available - so choose Covance. With pressure to substantially increase numbers of trial participants, increased scrutiny on product safety and stringent regulatory controls throughout the world, Covance is ready to partner and bring to the fore the expertise, resources and insight required to guide you through the complex and challenging c…
Total flexibility. Covance's Clinical Development services are customized to your specific needs. The stakes are high as your drug enters clinical development in Phase II-III. With your drug’s future on the line, you need to navigate a global maze of patient populations, practice patterns and regulatory requirements, often also languages and time zones, before the goal of regulatory approval is in sight. It’s challenging and…
Superior Regulatory Service Helps Transform Your Clinical Trials. Strong regulatory strategies are pivotal in getting products to market. While many countries’ drug regulations are similar, there are still significant differences. These similarities and differences are the basis of a global regulatory strategy that encompasses the needs of all regions. Serving you where you need to be, our Regulatory Affairs teams are located…
On-line analysis with our S2 KODIAK - Meet the future of process control. Achieve the next level of efficiency in mining and mineral beneficiation with S2 KODIAK! Real-time process control in the mine is vital in order to achieve optimal cost efficiency. At the same time, it is challenging to bring an analytical instrument into the process. The S2 KODIAK on-line XRF works autonomous and maintenance-free 24/7.It delivers immed…
microVISC is the fastest viscometer for your routine viscosity measurement. The viscometer is intuitively designed so that users can start operating within a minute. It employs RheoSense's patented Viscometer/Rheometer-on-a-Chip (VROC) technology and offers accurate and repeatable viscometry measurements, using sample size as small as 100 micro liters. Battery-operated and portable, microVISC can be deployed at any laboratory…
The Sievers 900 On-Line Total Organic Carbon (TOC) Analyzer is designed for continuous monitoring of waters from ultrapure to potable.It offers superior versatility, as well as accuracy and precision across a dynamic operating range of 0.03 parts per billion (ppb) to 50 parts per million (ppm).The 900 On-Line Analyzer utilizes a modular design and advanced materials for maximum reliability and uptime. Engineered for ease of us…
High-performance data acquisition hardware trusted for a wide range of life science research and teaching applications. The PowerLab data acquisition (DAQ) device is recognized internationally for its high signal quality, simple design and practical use in a wide range of applications. Few DAQs are cited in research as often as the PowerLab.PowerLabs are capable of recording at speeds of up to 400,000 samples per second conti…
The Next Generation tip refill system offers a complete refilling solution for laboratory pipetting procedures. Refills are available in 17 different tip styles to accommodate use with VWR pipettors as well as those of other brands. With a focus on environmentally friendly construction, each refill is a complete system with a low carbon footprint. Packaging is constructed from 100% renewable material, all recyclable portions…
Easily and accurately capture, find, re-use and share experiments—improving productivity, collaboration, compliance and collective intelligence. Electronic Laboratory Notebooks (ELNs) are rapidly becoming a core part of every laboratory operation in industries from pharmaceuticals, to chemicals, to consumer goods and more. ELNs streamline the documentation and protection of intellectual property, help scientists collaborate i…
Hematology Controls and Calibrators - Quality, Ready-to-run and Convenient. Mindray's hematology controls and calibrators are the original standards with which to evaluate the precision and accuracy of hematology analyzers. Backed up by world-class development and manufacturing, these hematology controls and calibrators offer the assurance of highest quality from your lab results. All of these hematology controls and calibrat…
Pipettors provide superior accuracy and precision for repeatably reliable results. Innovative new ergonomic design features allow for consistently comfortable pipetting, even throughout extended use. An extended, curved finger rest allows the pipettor to be comfortably balanced on the index finger, and both plunger and volume adjustment forces have been significantly reduced to eliminate the strain of repetitive pipetting. Vo…
For highly efficient total protein extraction from cultured mammalian cells. The complete cell lysis reagent is a nondenaturing detergent formulation that dissolves cell membranes and extracts total soluble cellular protein in only 5 minutes. M-PER Reagent requires little or no mechanical disruption and yields more protein than freeze/thaw cycles and sonication.This mammalian cell lysis reagent is so efficient that adherent c…
DDM 2910 – Digital Density Meter (Densitometer) is designed to meet the requirements of your laboratory applications in Chemical, Petroleum, Pharmaceutical, and Beverage industries. Digital Density Meter Model DDM 2910 Features: Measure API Values in accordance with ASTM D1250, ASTM D4052, ASTM D5002, DIN 51757, ISO 12185, ASTM D4806, IP 365, and ASTM D5931 Capable of multiple measurements with standard deviation, min a…
With advanced Q-Drive™ technology, the GeneMate Vortex Mixer provides a smooth instant vortexing of even the largest sample sizes, including full 50ml tubes. The unique counter balance system creates maximum vortexing action, while minimizing noise and excessive vibration. This results in quieter, more efficient and longer lasting operation.GeneMate Vortex Mixer Features: 2-year full replacement warranty! Powerful motor…
Plate sealing without heatng - the Fusion3™uses laser technology to seal microtitre plates. Microplate sealing is a technology that in recent years has struggled to keep pace with the advances in plate technology & density. Utilisation of the full potential of microplates, particularly high density formats, is often hampered by the need to seal with conventional heat based sealing systems. The scientists at LGC have a…
