The YMC-Accura Triart Bio C4 column for AAV capsid protein analysis

27 May 2024

Traditional methods such as ELISA and SDS-PAGE are labor-intensive and imprecise, whereas reversed phase liquid chromatography (RP-LC) coupled with mass spectrometry (MS) offers better accuracy for quantifying viral proteins VP1, VP2, and VP3. YMC Europe presents the YMC-Accura Triart Bio C4 column as the optimal choice for analyzing adeno-associated virus (AAV) capsid proteins, which are crucial for gene therapy applications. Further, YMC Europe highlights a study that compares the bioinert YMC-Accura Triart Bio C4 column to standard columns, demonstrating that the bioinert coating significantly improves resolution, peak shape, and retention times by preventing protein adsorption to the column hardware.