The Effects of LC Particle Choice on Column Performance

Superficially porous particles (commonly referred to as SPP or “core-shell” particles) have proven to provide fast and efficient LC separations. These particles feature a solid, impermeable core enveloped by a thin, porous layer of silica that offers significantly higher efficiency and sensitivity than traditional fully porous particles (FPP). In this application note, performance of Raptor™ 5 μm SPP LC column is compared to traditional 3 and 5 μm FPP LC columns. We will demonstrate how faster, more efficient analyses can be attained with greater sensitivity and reduced system pressure by switching from fully porous particles to superficially porous particles—without changing instrumentation.