Strategically defining operational parameters for a microcarrier-based mesenchymal stem cell expansion process within a single-use bioreactor

16 Nov 2022

In this white paper, Distek presents an elegant and scalable method for the onboarding of a simple, three-dimensional, microcarrier-based hMSC (Human mesenchymal stem cell) expansion bioreactor process. Results of the study showed an 11.9-fold culture expansion at 96.5% viability after a 6-day culture period.

BIOne 1250 Bioprocess Control Station

Distek, Inc.

BIOne 1250 Controllers are compatible with both autoclavable and single-use vessels. The systems are also capable of supporting both cell culture and fermentation processes. Standard controller options such as OPC and Additional Input & Outputs expand the capabilities of the controller. Such features provide end-users with nearly limitless process expansion potential for whatever future bioprocesses they desire to engineer.  

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Strategically defining operational parameters for a microcarrier-based mesenchymal stem cell expansion process within a single-use bioreactor