Raman Spectroscopy Analysis of Crystalline Polymorphs for Pharmaceutical Development
6 Sept 2015Crystal polymorphism is a phenomenon where compounds with the same chemical formula can be crystallized into different crystalline structures. In the pharmaceutical industry, the study of crystal formation techniques is very important for the control of crystal structure and the manufacture of high quality medicines. In this application note, crystal polymorphism is analyzed by dispersive raman spectroscopy using Jasco’s NRS-5000 Series Raman.
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NRS-5000 Series Raman Spectrometer
JASCO (USA)The performance and functions expected on a micro-Raman spectrometer are all provided with the NRS-5000 series Raman systems, assuring consistent performance for rapid acquisition of high quality data with automated system control and minimal optical adjustments. For application expansion, an automated multi-grating turret, 2 internally mounted detectors and a maximum of 8 lasers ranging from the UV through the NIR are capable of integration with the instrument system, all optical components are PC controlled for maximum flexibility with minimum user interaction. Features Research-grade model assuring high spectral quality Exceptional wavenumber accuracy with a high-precision rotary-encoder direct drive mechanism Low wavenumber measurement (NRS-5200/7200) Auto-alignment of microscope laser introduction optics and Raman scattering light path Wavenumber calibration using an integrated Ne lamp Unique Dual Spatial Filter (DSF) for higher spatial resolution than conventional confocal optics Patented Spatial Resolution Image (SRI) function for simultaneous observation of sample image, laser spot and aperture image Full range of options including macro-Raman measurement unit and fiber optic probes