Quantitative Analysis of Gabapentin from Serum by Reversed Phase HPLC using Discovery C18 Columns
20 Jul 2015Gabapentin is an analogue of +/-aminobutyric acid (GABA), a substance approved by the US Food and Drug Administration (FDA) for add-on therapy in treating seizures thought to be associated with interference in GABA-ergic pathways or provoked by excitory amino acids. Gabapentin circulates essentially unbound to serum proteins. This application note describes the use of reversed phase HPLC in the quantitative analysis of Gabapentin extracted from serum.
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Discovery C18 HPLC Columns
Sigma-Aldrich SupelcoClassic reversed-phases for all general-purpose applications. Features: Excellent peak shape and efficiency compared to competitive columns Classic reversed-phase retention and selectivity Excellent, no-bleed character for LC-MS applications C18 is generally more retentive than the C8 Column Details: Chemistry: C18 Particle Size: 5 µm Pore Size: 180 Å Length: 20, 30, 50, 100, 125, 150, 250 mm ID: 2.1, 3.0, 4.0, 4.6, 10.0, 21.2 mm