ResourceLife Sciences
Multiomic 6-base data from cfDNA enhances the performance of liquid biopsy classifiers
4 Feb 2025Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. Explore the results of a study that investigated the roles of 5- methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA). Using duet evoC for whole genome 6-base sequencing, cfDNA from 37 treatment-naive CRC patients and 32 healthy controls was analyzed.
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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Colorectal CancerLiquid BiopsiesLiquid biopsies are non-invasive tests used to detect cancer and other diseases by analyzing blood or other bodily fluids. This technique is gaining popularity for early detection, monitoring treatment response, and detecting minimal residual disease. Explore liquid biopsy solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.cfDNA